Dear sugber: I can certainly understand why you might be considering this treatment. Many of my patients with a history of breast cancer get a psychological as well as physical lift from having filler injections, or facial recontouring with fillers. You can be assured that letrozole is in no way a contraindication for filler treatments.The aromatase inhibitors can have detrimental effects on the skin, so it is helpful to take steps to counteract that. You might wish to consider topical medicated products or cosmeceuticals to rejuvenate the skin more superficially and prevent some of the deleterious effects of letrozole on the skin. Your dermatologist should be able to help you formulate a skin care regimen drawing upon a retinoid, glycolic acid, green tea polyphenol, resveratrol, vitamin C, and/or fibroblast growth-factor cream/gel/lotion/serum/peels.Truly wishing you all the best and wonderful health for decades to come,Dr. Clark
