Are there any negative side effects to drawing 60cc's for the P Shot?

It does not harm you in anyway if the practitioner wants to draw 60cc of blood from you in order to do your P shot. This is a common practice among providers when giving a P shot to ensure that you have enough PRP to perform the shot. However, it is up to the discretion and set up of the office providing the P shot on whether or not they think they need that much blood or if they are set up to process 60cc of blood for a P shot. You will have to ask your practitioner how they do their P Shots and if they are set up to do 60cc of blood for your PRP. Good luck, I hope this helps.

There are no negative effects from drawing 60 cc’s of blood for a P - Shot. The issue is, different PRP tubes that go into the PRP centrifuge mostly are 30 cc tubes or less. There is one centrifuge that has 60 cc tubes and that is the Magellan. There might be others I’m not aware of , but if you want 60cc’s of blood drawn you need to check with the clinic you are going to what type of centrifuge they have.

Drawing up 60 cc's of blood for the P Shot is safe. There are no side effects to drawing 60ccs of blood. PRP therapy involves injecting a concentration of platelets from your own blood into your body for healing. The benefits of this treatment on sexual performance may be attributed to increased blood flow and repair responses in some tissue or cells

The amount of blood drawn for a P-Shot—typically 60cc (or 60mL)—is minimal compared to the body's overall blood volume. The average adult has about 5 liters (5000mL) of blood, so 60cc represents only about 1.2% of total blood volume.

For comparison:

A standard blood donation is around 450–470mL, significantly more than what’s needed for the P-Shot.
Routine lab tests, like a CBC or CMP, use about 10mL each, with even a large panel rarely exceeding 60mL in total.
Drawing 60cc for the P-Shot is generally considered safe, especially for healthy adults, as it’s well within the body’s tolerance. This amount allows providers to concentrate enough platelets in the PRP to maximize treatment benefits without causing any noticeable impact on your overall blood volumegood

Thanks for your question. We have performed the P Shot since 2015. We use a "high volume" PRP kit meaning we routinely draw 60 or 120 ml of blood and have never had any adverse outcomes/events. The volume of blood draw is critical to the best outcomes from the procedure. We participated in research in this whereby we measured the patient's platelet count through a fingerstick and used a specially formulated computer program to determine based on that platelet count what the ideal blood draw volume would be to get the best level of platelets in the PRP. We did this because there is a certain minimum platelet count you want in order for the PRP to have the best angiogenic effect (creating new blood vessels). This research showed us time and time again that the 120 ml blood draw was the winner in producing the desired platelet count in the final PRP (which we also tested and documented!). Our results have been consistently rewarding. The process is called the Transcend Customized PRP Protocol. We use the Emcyte Pure PRP II kits which are one of the best in the industry and have both the 60 ml and 120 ml options. Hope that helps!

There should be no problem in drawing 60 cc of blood for the P Shot procedure, other than the cost involved. It's more important to consider how the PRP is prepared, because with the P-Shot, it's very important to have three things: (1) PRP with high concentration (over a million platelets per microliter), (2) PRP with a high purity level (less than 5-10% of red blood cell contamination), and (3) enough PRP to deliver a sufficient dose of platelets for the procedure, (for the P-Shot, we aim for 5-10 billion platelets). In general, with the P-Shot, we are looking to inject a final volume of 10 cc of PRP with a high concentration, purity and dose of platelets. This seems to be more important with the P-Shot than other PRP procedures, except maybe PRP for joint or hair restoration injections. You can't change the starting concentration of platelets in the blood draw, it's usually around 200,000 platelets per microliter. Each mL of whole blood would therefore contain 200 million platelets. If you could capture all the platelets in the starting sample of 60 mL, that means you would have 12 billion platelets. Unfortunately, no PRP system is capable of 100% capture, (also known as "platelet yield"). Yield usually ranges from 30-85% and the higher the yield, the more contaminated the final PRP usually is with unwanted red blood cells and white blood cells. There are systems which are able to remove "99% of red blood cells" but when the PRP is tested, they often lose more than half of the starting platelets. In other words, due to physics of the centrifuge, PRP systems which are good are creating high concentration do not have high purity, and systems that are good at creating high purity are not good at creating high concentration. This trade-off was shown in a review by Magalon et al in the Journal Platelets in early 2021, where they reviewed 36 different characterizations of commercial PRP systems in the scientific literature. Only 15 out of 36 systems were able to produce PRP with a concentration over 1 million platelets per microliter, which is the minimum concentration needed to meet the definition of PRP. These highly concentrating systems also had an average red blood cell contamination of around 40%, much higher than desired. On the other hand, there were two PRP systems tested which could produce over 97% pure PRP without red blood cells, but the platelet concentration was very low, even lower than the starting blood sample and over 90% lower than what would be needed to call it PRP. Testing the PRP during preparation and before use is the only way to know the concentration, purity, and dose. Ask about the system being used, make sure it's FDA and/or Health Canada approved, ask how much blood is taken to start with. This is especially important as most clinics don't offer in-house PRP testing and manufacturers' claims have not always been supported by independent testing.

It is not that there is a disadvantage, but you don't need that much volume for the P-shot. You need about 10 cc of PRP total to make it work.