Does the origin of hyaluronidase affect its effectiveness?

Question

Hi doctors, my aesthetic doctor failed to dissolve a vycross filler ... using a galenic preparation of hyaluronidase. I think one vial contains 900 i.u. of hyaluronidase diluted in 3 ml of saline. In Europe we do not have human- recombinant hyaluronidase isn’t available. We have ovine, bovine or swine hyaluronidase (1500 I.u. powder for solution). Does the origin of hyaluronidase affect its efficacy or is it only the concentration that matters?Thank you

Raffy Karamanoukian, MD, FACS · Answer

Fillers can swell and migrate unpredictably, especially when a filler with a high-edema quotient is used in thin areas. Our office uses disciplined approaches to help patients with acute or chronic issues related to hyaluronic acid fillers. We begin by assessing for any tissue compromise and advocate early treatment to avoid complications with vascular occlusion. In chronic issues, it is important to gradually break up and dissolve filler so there is no further migration of loose filler substrate. Conservative staged dilution may also help avoid volume loss. If the filler is not dissolving, we may consider stronger concentrations or surgery.

Best,
Dr. Karamanoukian
Realself100 Surgeon

Best, 
Dr. Karamanoukian
Realself100 Surgeon

Does the origin of hyaluronidase affect its effectiveness?

Answers (1)

More Hyaluronidase Questions

Does the origin of hyaluronidase affect its effectiveness?

Answers (1)

More Hyaluronidase Questions

Fake filler left my face deformed- won’t dissolve and drs just say you look fine. Options? (photos)

How many units of hyaluronidase are usually needed to dissolve a Vycross filler?

Have doctors had success dissolving Vollure placed more that 3 years ago?