The exact duration of the effects of Sculptra can vary depending on several factors. Unlike other fillers, the volume produced by Sculptra is not a result of the product itself, but on the patient's own collagen production that is stimulated by the product. The actual Sculptra particles are very small and are probably degraded by the body in 6-12months. Think of the Sculptra as "fertilizer" for collagen growth. If more treatments are done (3-5 are usually needed), then more collagen is produced depending on the volume needed for full correction. This volume decreases with age just as it did the first time. In patients who are older, who had less volume to start with, or who had fewer treatments, the results will decline more quickly. Many patients retain their results for a minimum of two years and as many as five years with one or two touch-ups.