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What Are the Long Term Effects of Using Hyaluronic Acid Fillers?

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If hyaluronic acids (juvederm, restylane, radiesse) are injected to the cheeks / face for over 20 years or more, what are the possible side effects? Are there studies for the use of these fillers for that long to determine their safety in long-term use?

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Dr. Stephen Prendiville, MD
Board Certified Facial Plastic Surgeon
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Dr. Hadley Claire King, MD, FAAD
Board Certified Dermatologist
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