What Are Potential Latisse Side Effects?

Can Latisse cause any side effects I should be aware of?  If so, what are they and how long do Latisse side effects last?

Doctor Answers 26

Anticipate Minimal Side Effects

It’s unusual to see complications following the use of Latisse. Fortunately, when complications do occur they tend to be self-limited.Common complications include eye irritation, eye redness, eyelid itching and eyelid hyperpigmentation.These usually resolve when Latisse is discontinued.
In patients with light colored irises Latisse can rarely change the iris color to brown.Unfortunately, this is probably a permanent change.If any of these problems occur it’s important to notify your physician as soon as possible.

Latisse Side Effects

Fortunately, side effects from Latisse are uncommon. There is no evidence to suggest that Latisse will change your eye color. Over two million prescriptions for Latisse have been filled with no confirmed reports of iris pigmentation issues. Side effects from the initial studies showed less than 4 percent of people experienced redness, irritation and itching of the upper eyelid, which was reversed upon discontinuation.

Mitchell Schwartz, MD
South Burlington Dermatologic Surgeon
5.0 out of 5 stars 10 reviews

Side effects of Latisse

1. Itching of the eyelids

2. Darkening of the iris

3. Darkening of the eyelid skin

4. Worsening of eye diseases such as uveitis, allergic conjunctivitis, iritis.

It is important to have an ophthalmologist check your eyes before and after Latisse usage and to be aware that you are using it. 

Chris Thiagarajah, MD
Denver Oculoplastic Surgeon
5.0 out of 5 stars 7 reviews

Latisse Side effects

Latisse is a prostaglandin analogue similar to the drug bimatoprost used in the treatment of glaucoma.  

Some of the potential side effects are:

1. Darkening of eyelid skin (usually reversible once the drug is stopped)

2. Color change of the iris:  this may occur in lighter colored patients and usually turns the eyes brown.  This is sometimes permanent.

3. Redness and itching which is resolved on discontinuation of the drug.

4. Unwanted hair growth in adjacent areas that come in contact with Latisse.  This can be minimized by apply Latisse carefully only the lash margin of the upper eyelid.

Side Effects of Latisse

Latisse is a prescription medication, which if used  correctly, does not often cause side effects. Nonetheless, we do recommend an eye examination before you initiate treatment and 12 weeks later, as well was yearly after that.  As with any medication, the benefits and risks must be weighed so it is important to use the product correctly and be observed for side effects.

Sandy Feldman, MD
San Diego Ophthalmologist
4.5 out of 5 stars 2 reviews

Latisse Generally Has Few Side Effects, but It's not a Risk-Free Product

Latisse is only available via prescription after a physician has learned of your ocular history. Therefore, complications with Latisse are relatively few, although Latisse itself is not a risk-free product.

Some common issues include: blurred vision; dry eyes; eye swelling (edema); hypersensitivity; ocular irritation; rash; skin discoloration; and temporary loss of some eyelashes and/or eyelash breakage. It is important to note that since most of these symptoms were learned of after Latisse had been debuted on the market; therefore, it is unknown precisely how many Latisse users suffer from these symptoms. However, most of my patients have used Latisse without issue.

While less common, some patients have been known to develop the following after using Latisse: discoloration of soft contact lenses; infection of the eye/ocular area due to a contaminated applicator brush; fluctuations in intraocular pressure; intraocular inflammation; hair growth outside of the treatment area; discoloration of the eyelids; and iris discoloration.

Since patients can only receive Latisse via prescription after discussing their ocular health with a doctor, it is unlikely that most patients will develop any of these adverse effects, at least for a prolonged period of time. If any adverse effects do occur, most are resolved shortly after discontinuing use of Latisse.

Common Latisse Side Effects

Latisse is an FDA approved prescription treatment for hypotrichosis (inadequate or not enough lashes) and is effective at helping lashes grow longer, fuller and darker.
The most common side effects when using Latisse is eyelid skin darkening and is reversible when discontinuing usage of Latisse, this eyelid darkening is similar in appearance a light brown eye liner having just been drawn on. Other common side effects are itchy and red eyes. However, this depends on the patient; we have many patients with very sensitive eyes that have never experienced those side effects when using Latisse. For patients that do experience itchy red eyes when using Latisse, we typically find that after several weeks of initial usage, any itchy or redness has subsided or stopped. For optimal results discuss this with the prescribing physician or staff members to further aid you in the process.

Frank Barone, MD
Toledo Plastic Surgeon
5.0 out of 5 stars 38 reviews

Side Effects are very uncommon

The most common side effects after using LATISSE solution are an itching sensation in the eyes and/or eye redness.

George T. Boris, MD, FRCS, FACS
Los Angeles Facial Plastic Surgeon
4.0 out of 5 stars 14 reviews

Latisse side effects

Side effects of Latisse:

darkening of the skin in the area
eye dryness

One very rare risk is an increase in brown pigmentation in the irises in green or hazel eyes. However, I haven't seen this occur with any of my patients to date.

Side Effects of Latisse

The most common side effects after using Latisse are an itching sensation in the eyes and/or eye redness, skin darkening, eye irritation, dryness of the eyes, and redness of the eyelids. In the original FDA study, about 4% of patients had these side effects. In our experience, nearly all patients tolerate Latisse well. There often is a slight effect of skin darkening along the lash line which is tolerated because it gives the appearance of eyeliner. This slight skin pigmentation resolves once Latisse is discontinued.

There has been information floating around about Latisse changing eye color. First, Latisse was developed from prescription drops used to treat Glaucoma called Lumigan©. Lumigan is an FDA approved eye drop prescription since 2001, meant to be placed directly on the eye daily. In the original Lumigan FDA clinical trials, there was a 1% incidence of hyperpigmentation (or darkening) of the eye color (the iris) in patients with hazel or light brown eyes. In the six years since the release of Latisse there has been NO REPORTED CASES of eye color change due to Latisse that I am aware of. With Latisse the product is applied along the lash line and studies have shown when properly placed, little if any gets on the eye itself. As such, the safety literature that accompanies Latisse mentions this rare risk of a reaction and permanent darkening of your eye color.

David J. Myers, MD
Salt Lake City Dermatologic Surgeon
5.0 out of 5 stars 3 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.