According to the manufacturer's directions, Latisse should be applied daily using a disposable brush which is included with product. Latisse is to be gently applied along the base of the upper eyelashes. Immediately after the application of Latisse, while your skin is still damp from its application, blinking will transfer some of the product to your lower lashes so it is not necessary to intentionally apply it there. Latisse can enhance the growth of hair in other areas besides the upper eyelashes. For example, many of my patients have successfully used Latisse to enhance the growth of their eyebrows.