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It’s not recommended to put Latisse on the lower lashes because there’s more of a chance of getting the product into the eye. Also, Latisse wasn’t studied in the lower lashes. My experience is that people who use Latisse on the upper lashes will still get some growth on the lower because just from blinking some of the material will be transferred to the lower lashes.
Latisse is FDA approved for use on the upper eyelids at bedtime. Application to the lower eye lids may increase skin pigmentation and hair growth outside of the eyelid margin, if the drop runs down the eyelid margin or face. Application to the upper eyelid will help both the upper and lower lashes.
Latisse needs to be applied to the edge of the upper lid at night time. It is not applied to the edge of the lower lid because it does not have to be. The contact between the lids when you sleep places the Latisse where it needs to be and minimizes applications directly on the eye where it may darken the eyes (like its eye drop predecessor Lumigan).
According to the manufacturer's directions, Latisse should be applied daily using a disposable brush which is included with product. Latisse is to be gently applied along the base of the upper eyelashes. Immediately after the application of Latisse, while your skin is still damp from its application, blinking will transfer some of the product to your lower lashes so it is not necessary to intentionally apply it there. Latisse can enhance the growth of hair in other areas besides the upper eyelashes. For example, many of my patients have successfully used Latisse to enhance the growth of their eyebrows.