Should Latisse Cause Bloodshot Eyes and Irritation?

Blood shot eyes are not the typical response to Latisse. If the product is used in excess, it can get into the eye and cause the symptoms that you describe. It is usually best to stop using it until your symptoms clear.
If you should decide to try again, ensure that you use only one drop and apply it to the eyelid a few millimeters above the lashline. If it starts to drip into your eye, dab the area with a tissue. If this does not solve the problem, consult with your prescribing physician.

The side effects you mention are not that uncommon...though very bloodshot eyes are not common. Some redness and irritation are expected for some patients (not all) and those symptoms go away fairly quickly.  So, yes, you should expect those effects to lessen as your eyes become "used to" the medication.

Don't overuse Latisse. More is not better and can cause unwanted excess hair growth should it drip or be applied to other areas besides the lashline. Always blot any excess and use it only once a day.

Good question. Yes, Latisse may cause eye redness and irritation in certain individuals. The side effects may lessen over time, but the best way to minmize these effects is to keep the medication localized to the upper lid only. This can best be achieved by blotting excess fluid with a tissue. Sometimes placing a clean kleenex underneath upper lashes and closing lid down on the tissue while applyng the medication can help avoid droplets going into the eye itself.