Stretch marks can be quite resistant to treatment but there are several methods that have been proven to be effective. Unfortunately, chemical peels, including those using glycolic acid, are not among them. Tretinoin cream (prescription-only) has been shown to improve the appearance of stretch marks by stimulating the production of new collagen causing thickening of the skin. Also, a new treatment using fractionated bipolar radiofrequency energy called "sublative rejuvenation" with the eMatrix machine has been proven to be successful in the treatment of stretch marks as well as acne scarring. This is because the eMatrix only minimally affects the epidermis with most of its effect being in the deeper tissue (dermis).