Do I need to apply hydroquinone before and after PicoSure treatment? (Photo)

Hi Bin.  It appears you have some sun or age spots, but it's difficult to tell if you also have Melasma.  If you have age spots, then a proper q-switched Picosure treatment or two should remove them permanently.  These spots are usually smaller, circular, brown and have easily defined borders.  
Melasma, on the other hand is usually diffuse patches of pigment on the cheeks that are larger than sun spots and very symmetrical from side to side.  Melasma is chronic and there is no cure.  We would also not recommend Picosure for Melasma as the condition can worsen.  We do use hydroquinone for Melasma. 

In spite of the effectiveness of Picosure, use of hydroquinone between treatment intervals can be advised depending on the doctor's judgement.   In order to use it for the "rest of your life", it should always be done under a doctor's supervision.

your skin is not very dark and the Picosure laser does a good job of resurfacing with no downtime. you can see how you do without pre-treating with HQ and just see what happens over time. plan 3 treatments done each about a month apart.david berman md