For many patients, gravitational effects result in sagging of the cheek fat toward the jawline, creating a loss of volume in the cheek area. If this is the case, then a MACS lift, which is a short-incision facelift, with internal repositioning of the facial tissues can restore volume in a very rejuvenating manner.
Another cause of loss of volume is facial atrophy, which can occur with aging or weight-loss. In this situation, it is usually better to add more volume by facial fat grafting (or transplantation). New techniques for fat grafting are very promising with water-assisted liposuction (body-jet, WAL) for fat harvesting which provides for healthier cells with better and longer lasting results. Facial fillers, or "liquid facelift", such as Radiesse, Juvederm and Sculptra are only going to provide small volume increases most effectively over facial structures such as over the cheekbones. My preference in facial fillers would be Radiesse since it provides better volume, lasts longer and is more cost effective than some of the other fillers. It is always wise to seek out a board certified plastic surgeon with experience in facial aesthetic surgery. They would be able to help you with your particular goals, and perhaps a combination of above procedures would be optimal.