Is eyelid discoloration a side effect of Latisse?

Hyperpigmentation may occur to the skin where Latisse is applied. It is usually progressive and will dissappear as fast as it came once the use of Latisse is discontinued. This is a non-permanent side effect that happens quite often. Several of our patients have tried stopping the use of latisse until the hyperpigmentation went away and then resumed successfully. Ideally, the hyperpigmentation darkens only the skin at the root of the lashes and would look like fine eyeliner. Unfortunately, product leaks or is poorly applied and leaves undesirable stain patterns outside the lash line. Here are  few tricks to try:


With water, wet the applicator brush and squeeze the water out with your thumb and index. This will flatten the brush to insure precise application. You will also use less product as it absorbs less into the bristles of the brush.

Apply latisse well after skin is dry from washing or showering.

Let Latisse penetrate and dry well before applying creams around eyes and and shutting your eyes for the night.

Eyelid discoloration/darkening can occur from using Latisse on the eyelids, just as iris discoloration can occur from putting the drops in the eye directly (as people do who are using the formulation for treating glaucoma). Unlike the iris darkening, which is usually permanent, the eyelid discoloration should resolve with discontinuation of the product, although this make take some time.