Most likely they are not harmful. But it is a ethical question of using out of date fillers. The old 'what if' issue comes into play. If you had a reaction from out of date fillers then the doctor has preformed malpractice and has license issues. An example in a sense that I was involved in here in Miami, I saw a patient 3 or 4 years ago who had an eruption nodule on her lateral upper lip for over three months. She had implants from me years earlier but decided to use a Latin Clinic for her fillers. I guess to save a few dollars. She stated she had Zyderm injected but was not sure. On examination there was an ulcerated nodule of the lateral upper lip less than 2 cm. No exudate was seen. I started her on PO antibiotics and steroid low dose injections. The eruption and ulceration cleared in 2 weeks but the nodule only decreased by 50% after 3 injections of Kenalog 10%, 0.1 cc's. I had her request her records from this clinic. It took her 3 months to obtain a one page office note. During that 3 month interval, she had another episode of swelling in the area which I treated. Upon review of this record, it stated she indeed was treated with Zyderm. A label was a fixed to the injection date. The next observations were very insightful. The date of expiration was 8 months earlier, well after the injection date. And NO TEST DOSE WAS DONE! So 2 areas of falling below the standard of care. But it gets better! I did a biopsy the nodule with a pathology report in a few days stating Silicone granuloma. Unfortunately this clinic had no insurance so there was really no recourse for this patient. The point is be careful out there.