Spironolactone lowering testosterone?

Question

If spironolactone lowers testosterone in a female to low levels, can it increase hair loss due to the lack of testosterone? And would any hormonal changes revert to normal is spironolactone is stopped?

Anna Chacon, MD, FAAD · Answer

Spironolactone is a medication that is often used to treat conditions like high blood pressure or fluid buildup. However, it also has antiandrogen effects, meaning it can block the effects of certain hormones like testosterone. In women, this can sometimes be used to help treat conditions like hirsutism (excessive hair growth) or acne.

If a woman has high levels of testosterone, spironolactone may help to reduce these levels and potentially alleviate some symptoms. However, if a woman's testosterone levels are already within a normal range, reducing them further could potentially contribute to hair thinning or loss, as testosterone plays a role in hair growth.

If spironolactone is stopped, hormonal levels should gradually return to their baseline levels, assuming there are no other factors affecting hormone production. However, it's important to note that the body's response can vary from person to person.

It's also important to remember that hair growth and loss can be influenced by a variety of factors, not just hormone levels. Other factors like stress, nutrition, and underlying medical conditions can also play a role.

As always, any concerns about medication side effects or hormonal changes should be discussed with a healthcare provider. They can provide personalized advice based on a patient's medical history and current health status.

Matt Tahsini, MD · Answer

Hello and thank you for your question.  If a female hormonal range is normal Spironolactone could lower hormonal levels more and cause hair loss. Once Spironolactone is discontinued levels should return to normal.  I do suggest you discuss this with your doctor to determine your path forward. Best of luck to you.

Dr. T

Spironolactone lowering testosterone?

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Spironolactone lowering testosterone?

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