Hello, Thank you for your question regarding polynucleotides and their potential to cause an occlusion. Polynucleotides are often used in aesthetic and medical treatments for their regenerative properties. They are generally considered safe when administered correctly. However, like any injectable treatment, there is a theoretical risk of occlusion, particularly if the product is inadvertently injected into a blood vessel. This risk is relatively low but underscores the importance of having such procedures performed by an experienced and qualified healthcare professional. If you have any specific concerns or are considering a treatment involving polynucleotides, I recommend consulting with a board-certified dermatologist or medical professional who can provide personalized advice based on your medical history and treatment goals.