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Can the Use of Retinoids Cause Skin Cells to Reach Hayflick's Limit?

May 17, 2009

My concern is that through the continued use of retinoids and the resulting stimulation of cell renewal, skin cells would eventually reach Hayflick's Limit. Is this true or likely?

Answers (1)

From board-certified doctors and trusted medical professionals
Dr. Otto Joseph Placik, MD
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Dr. Otto Joseph Placik, MD
Board Certified Plastic Surgeon
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Answered on May 18, 2009
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Benjamin Bassichis, MD, FACS

Rather than nag you to quit, here are some facts: Smoking destroys collagen and elastin, and it decreases estrogen levels, which are necessary to keep skin firm. And significantly impairs healing after procedures and surgery. Don’t forget about causing cancer – and wrinkles. No...

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Jason Hess, MD

Retin-A has been available via prescription for decades.  When a medication is on the market for this period, it generally indicates that it is "tried and true".  It is accepted among dermatologists and plastic surgeons alike that Retin-A helps to alleviate fine lines. ...

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David Hansen, MD

Retin A doesn't cause permanent wrinkles. It is a collagen promoter and mild exfoliator which can cause crinkling of the dead skin as it is getting ready to lift off the old skin. If the old dead skin doesn't come off all at once then continued use of retin A or a chem peel will get the rest...

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