A closer, in-person examination would be helpful. However, two possibilities come immediately to mind when looking at the photo. One is a line that arises from static tension of the muscles of the glabella (frown area between the eyes) region. A second possibility is a localized scleroderma condition known as "En coup de sabre.," so named because it looks like the result of a slash of a sabre For the former condition, Botox would be helpful for relaxing the intense static muscular tension that gives rise to the line. And, if, after years of static tension, the overlying skin has become etched or creased even in the relaxed state, a low viscosity, malleable, cohesive HA filler, as a second step, can be injected to elevate and smooth the residual crease. If this is "En coup de sabre" and has been stable for a long time, the above HA filler can be used to elevate and smooth the depression. This is precisely what I did with excellent results for my wife who has this condition. It would be wise to consult with an experienced, board certified cosmetic dermatologist injection expert who can both diagnose and treat these issues. Best of luck. .