Good Day. Bellafill has been shown by previous studies and a current clinical study, presented at a recent cosmetic surgery conference by myself, to be safely injected in all facial areas, except for the bulk of the lip. Most physicians who are negative in the use of the product, lack adequate experience. How do I know this? I used to be one of them. I thought, why would you want to inject a plastic type material in a dermal filler in your face. I had, and other physicians may have, the following concerns: 1. Granuloma formation (firm area) 2. Risk of infection 3. Concern of treatment of over-injection The answer to these questions may lay most of your concerns. The incidence of granuloma formation in four studies for FDA approval showed an incidence of 1.7%. I have injected over 1600 syringes and have had no granulomas. A medical practice I became medical director, who injected Bellafill from 2007 to 2013 had three small granulomas, all of which resolved with 1-3 Kenalog injections. I have never seen a patient with a facial infection associate with Bellafill. PMMA, a component in Bellafill, is used safely in neurosurgery and maxillofacial surgery. Careful injection of any filler (not to over inject) is essential. If more filler or volume results, Kenalog and 5-FU can be injected to absorb the volume created by collagen production. Rarely is surgical excision necessary. In my experience, 2 patients requested surgical excision who refused steroid attempts. Facial Volume Replacement Options: Temporary: 1. Hyaluronic acid fillers, such as Restylane an Juvaderm 2. Sculptra or L-Lactic acid to stimulate collagen synthesis. The manufacturer suggests that the volume effect lasts about two years. Permanent: 1. Facial silastic implants 2. Facial fat transfer with platelet rich plasma and stem cells 3. Bellafill. Injection in the proper anatomical site, injecting amounts that are not excessive, and minimizing side effects by using a microcannula. In my expert opinion, if you are desiring cheek or malar fullness with no other areas of volume loss, a silastic malar or combined mid face implant, is best. The other advantage of the implant is that it is the best technique to provide a face lift of the overlying soft tissues. When there is significant facial volume loss throughout, facial fat transfer adding platelet rich plasma, processing the fat for purification, such as in the MediKan centrifugation and filtration system and possibly adding your own stem cells (proper nomenclature is stromal vascular fraction cells) is best. Two thirds of the volume injected remains long term, since about 20% of the fat cells die and 15% of the injected volume is salt water, that leaves two thirds of the tissue remaining. Additionally, you can store unused harvested fat in a cryo bank, such as American Cryostem, for future injection. The fat transfer volume will finalize within 2 months and thawing of the stored fat, FedEx to your office over night and then reinjection to ares of the face that remain deficient would be recommended. Also, Bellafill is the only dermal filler FDA approved for injection for volume replacement in acne scarring patients.Smaller needed volume of a permanent filler may make Bellafill the best choice in this situation. In summary, Bellafill is a safe long-term filler (most likely permanent) that can be used in any anatomical areas of the face, except for the bulk of the lip. Any fillers expertise is not necessarily in the filler, but in the injector! Alternative permanent volume options include fat transfer or silastic implants. Good luck with whatever treatment option you choose. Remember, no treatment is an option as well.