2.5 weeks post hyaluronidase, and now have a deep trough, did it dissolve the tissue?

Hyaluronidase will not dissolve your normal tissue, only the hyaluronic acid dermal fillers. There can be swelling after the injection and it may take a couple weeks to see the final result.

Hi and thank you for your question! Hyaluronidase works by dissolving hyaluronic acid (whether it's injected or the naturally-occurring hyaluronic acid of extra cellular matrix). So, in theory hyaluronidase can result in volume loss in areas of injection. If that's the case, any lost volume can be restored by injection of hyaluronic acid fillers. However in your case since you have various treatments, I highly recommend that you discuss this with your physician and do an objective assessment by comparing pictures taken before and between the procedures to determine which issues were preexisting and which are new. Objective comparison of pictures is the most effective way to address these concerns and I hope your physician has obtained them. I hope it helps and good luck! 

Hyaluronidase won't dissolve your tissue. However, it may take a few weeks after hyaluronidase for your tissue to go back to normal. Keep in mind, a combination approach will give the most improvement for under the eyes. Fillers, lasers, and microneedling/PRP can improve under the eyes. My patients try to get non surgical treatments to avoid surgery. We use PRP and stem cells there often. I suggest consulting with an expert to develop a treatment plan best suited for your short and long term goals. Best, Dr. Emer

No, hyaluronidase will not negatively impact your natural tissue. It can take a few weeks for hyaluronidase to resolve. Hope this helps.