How to Safely Apply Latisse with Contact Lenses On?

You should remove your contact lenses before applying, and wait about 15 minutes afterward before re-inserting. If you cannot see anything, you can try a magnifying mirror to help you. 

The Latisse goes onto the skin above the eyelashes. As long as the individual sees what she is doing, I see no reason why contact lenses should be removed or that the procedure should be altered.

Unlike LUMIGAN, its more concentrated predecessor which was supposed to be applied to the eye for the treatment of glaucoma, Latisse must ONLY be applied to the junction of the upper lid with its lashes just before bed time. It must not be applied to the eye itself.
Good Luck.

Latisse is meant to be applied at night after lenses are removed. It also is not supposed to go into the eye. If you truly cannot see then you could apply Latisse 1st and then remove the lenses. Be careful not to get any into the eyes and if you do remove and rinse the lenses immedialtely.