I have suffered with cystic acne for many years. Hormonal related acne which affected mostly my T-sone areas. Isolaz is the only treatment that has made a significant difference. I had a series of four treatments and after a month, I really noticed that my breakouts were significantly less frequent and less severe. NO cystic acne flare ups! when I break out now, it clears up in a matter of a couple of days versus 10 - 14 days. Be sure to find a qualified doctor to do the treatments. Not painful but slight discomfort like the snap of a rubberband...very minmimal.