Perlane vs. Restylane, what's the difference?

Perlane and Restylane are both superior dermal fillers made, and are both made with hyaluronic acid (HA). The main difference between Restylane and Perlane is their particle size and consistency.   Restylane has a thinner consistency and uses smaller HA particles.  It... more

Many posters with essentially the same answer. I chose to tell patients a very simple explanation. Restylane is thinner less thick substance while Perlane is the exact same product but three times thicker. Perlane is harder to inject, but lasts 3x longer, cost is double of Restylane. Very simple answer.

This question has already been answered pretty well, so I will explain how I use Perlane and Restylane in my practice in Dallas, Texas.  The trade off is that Perlane is much harder than Restylane but it lasts much longer.  I like Perlane for the cheeks and chin and for smile lines.   I use... more

Restylane and Perlane are both hyaluronic acid fillers manufactured by Medicis. While Perlane and Restylane are composed of the same material, Perlane is composed of bigger particle size and is consequently thicker. Due to its bigger size, Perlane is more resistant to degradation and can last longer. Perlane... more

Thanks for your question.  You are correc that both of these fillers are comprised of Hyaluronic Acid.  The difference is in the size of the molecules and what we use the products for.  Restylane is a smaller product and is used for fine to moderate lines as well as lips.  Perlane is a... more

Both Both are made by Medicis Both are hyaluronic acid based Both cost in the $500-600 dollar range in our office per syringe Restylane Comes in a "half" syringe (0.4 cc) Has a slightly smaller needle than Perlane for injections (thus it might hurt less) Can be injected more superficially Works... more

Think of them as starting from the same jello like substance and then pushing that jello through a strainer. If you use a pasta strainer then you get perlane. If you use a sifter for powdered sugar you get restylane. Forgive the food analogy but this seems to make sense to eveyone. As to what is best used in... more

Great question. I would make a few suggestions. As you know that Perlane tends to last a bit longer than Restylane by perhaps 6-8 weeks or so (when injected in to the lips). You want to make sure that your doctor has experience with fillers in the lips as the lips require a great deal of skill and... more

Restylane and Perlane are both hyaluronic acid fillers made by Medicis. Perlane has larger particle size and is thus more thick or dense and better suited for deeper fold or for deeper volume filling as in the cheeks. Restylane is the perfect choice for many patients but sometimes I choose Perlane... more

Great question.  Both products are hyaluronic acid. They differ in what is called crosslinking of molecules and of concentration of the hyaluronic acid in the product.  Restylane is generally softer and used for superficial wrinkles and lips. Perlane is firmer and is used for deeper wrinkles. Perlane... more