Can Botox Treat Facial Angioedema?

Jennifer,
Judging from the photo, you are a very attractive person and certainly don't manifest any overt sign of angioedema there. Unfortunately, I know of no reports recommending the use of Botox for the management of this entity. Hopefully, you are under the care of an allergist or immunologist. If so, for now, stick with your current protocol. It seems to be working phenomenally well. Good luck!

I’m not aware that Botox would prevent the angioedema, but I would caution you that you would risk difficulty utilizing your important smile, eating and speaking facial muscles if Botox were to be administered in the cheeks.
There is a certain amount of diffusion (spread) of the Botox (about the size of a dime to a quarter) depending on the dilution used, and the dose in units can also affect the response. So, if it would decrease the Angioedema, the injections would have to be superficial to try to avoid the muscles below, but they still might become affected and you could develop temporary facial “paralysis” for several months, giving the impression of having had a stroke.
Be careful about this off-label use as I am not aware of Botox having been studied for this condition.

Botox has no reported effect on angioedema. However, we have determined that Botox can affect non-cosmetic problems such as excessive sweating and migraine headaches. Therefore, I would start with a conservative dose that would normally be used to treat the forehead and around the eyes. If you see some improvement in these areas on the left side, consider expanding the treatment area.