Restylane side effects - what did you experience?

Had Restylane to my chin just yesterday. Iced before & after. Doc used lidocaine in the injection with the product, I believe. I had a very small amount injected, absolutely no problems. Very slight swelling. Icing helps. It's the 2nd day, a tiny bit of bruising but it seems to be disappearing. The wrinkles I hated are nearly gone already & it's been under 24 hrs. I didn't lay down for 4 hrs. after treatment, slept as normal overnight, did not exercise after treatment, tho I will today. The doctor was great, very minimal discomfort at all, and no serious reactions. I am pleased so far. But after reading these posts, I do not think I'll do this procedure near my eyes. Doc has not suggested that anyway.

I bought hyaluronic acid filler restylane from china and 3 weeks ago I injected under eyes and chicks, after 3 weeks circle bumps appeared. please advise. thanks

I have spent two days searching for reactions people have had because of my reaction. I've decided to take 5 minutes and do a write up for all women like me who are having a reaction and in a major panic about it. Here we go: I had Restylane last year for my laugh lines. I was 40. It lasted a year and 3 months for me before it was time for a second round. I had it Tuesday at noon. Same dose as before. I had a block put in before the Restylane. The only thing we did differently this time vs. last time was they put a topical numbing creme on, waited a while, did the block, waited a while, then got the Restylane. By late afternoon, I was completely and totally swollen. Like, blown up, like a ballon, swollen. By that night, I was itching, burning, and in so much swollen pain I was going crazy. I took a Benadryl, then Tylenol, and not very much relief. I finally caved and took a Vicodin. That helped with the pain. I was very miserable. I was icing every hour. I could hardly sleep. I was very miserable and hating myself for getting the procedure (I was in tears). My first experience with the product last year did not have those results, I had a weird smile for about a day, a little hardness, and that was it. It was perfect. This time I looked like a freak and was having so much itching/burning I was going crazy. Wednesday (the following day), I woke up at 5am and started icing again. Tylenol. Benadryl. I was still swollen (I think more swollen than Tuesday night). The itching/burning had subsided (still was some up until that afternoon, then died out). But I was completely blown up like a freak show. If you asked me to smile, I looked like the Joker. It was awful. It totally freaked me out. I heard about Arnica Montana on some blog (I was internet surfing like crazy with my symptoms...not a good thing, lots of horror stories out there) and rushed down to the store and bought both the cream and the pills to try to calm the swelling and prevent bruising. I slept that night with three pillows under my head to try to drain the fluid. I didn't have to take the Vicodin, but I did keep up with the Benadryl (I don't think that was doing anything, really) Tylenol, and the Arnica cream/doses. Today is Thursday. I woke up and felt my face. It had gone down in swelling about 50%. I started to see movement. When I smile, I still look like the freak Joker. But now not so painfully blown up. I made an appt with my doc first thing this morning in this panic. He thinks I had an allergic reaction to the topical which he thinks amplified the condition. He is very confident this Joker smile is totally related to the swelling, and will be gone in a few days, at max two weeks (no promises, but he thinks). So no smiling, I guess, in the meantime. If I had to do it all over again (trust me, this makes me think twice), here are my suggestions for those who care: 1. Make your appointment when you don't have to see one human for at least 3 days. That means no events, work, etc. If your face was as bad as mine was, you don't want anyone to come anywhere close to you. Better if you were able to escape to another planet for one full week. 2. Seriously, no IB Profin, Aleve, Advil (the vowels!) prior to the treatment, for two weeks. I didn't, but boy, this experience really made me get real serious about that real quick. 3. Take Arnica 2 days before the treatment. Get it at a local Vitamin store for under $10. Ice before the treatment. Ask questions (how much, how long, check the box for the product, etc.). Ask who to call in case there was a problem. I would come in with clean skin (no makeup) and make sure they clean you really well when they inject. Just one more variable to take out of the equation, if there is a problem. 4. Immediately after: Sit there and ice. For like 15 minutes. Wait a bit to apply makeup. Don't work out for 24 hours. Ice every hour for 5 minutes, if you can. Benadryl and Tylenol following treatment. Keep head elevated when you sleep. Drink tons of water. Keep up on your Arnica cream, medicine, etc. throughout the night. 5. The next day was the worst for me swelling wise. Keep up your medicine. Don't plan to exercise for another 24 hours. Ice all day if you can. Drink lots of water to flush things out. When you go to bed that night, elevate your head. For two days after treatment, don't do any blood thinners (IB Profin, etc.) just try to relax. Oh! And no rubbing, no moving the product. Just let it rest. You can make it worse rubbing it all around. 6. This should be your full second day. Like I said, my swelling had gone down 50% by doing as much as I could of the above. Still took the arnica all day and Tylenol. Drank lots of water. By the evening, I worked out for about 45 minutes...lightly, to start everything moving around and try to get these fluids out of me (and not cause bruising or additional swelling). That is where I am at right now. I'm fairly confident I'm on the way back to normalcy. Please, if you have a similar experience, call your doc (you paid a lot of money for this, it's worth the Followup), and try to keep calm. The swelling will go down. Every hour today it's decreasing. I swear the Arnica is helping. I look slightly normal, but no smile with teeth (joker!). Don't panic. It will get better. The doc said in two weeks, I will love the look, like I did before. Stay calm and carry on! I hoped this helped someone. I know it would have helped me!

Hey, though I didn't go for restylane, my friend did it a few months back. Initially, it did bruise. Also, she had swelling and found lumps under her eyes after the treatment. But, she got it right after few weeks and now it's working really fine for her. It also depends on individuals' skin, as well.

i did a LOT of reading on sarcoidosis since i had so many symptoms - scholarly articles...personal youtube videos etc...i dont care if i have it or not - if the prednisone works i am staying on it for the recommended time. Day one on 40 mg prednisone i'm 60% better!

Do any of you who have experienced recurring swelling episodes after fillers to the tear troughs also have lumps and nodules when the swelling goes down? That is what is happening to me. My doctor now thinks that I am forming biofilms -- https://en.wikipedia.org/wiki/Biofilm -- formations of bacterial colonies. Apparently, this is a risk from fillers. He is now treating me with antibiotics. He told me to give it a week to see if there is improvement in the nodules and swelling. If there is improvement, I will continue the antibiotics for 6 weeks. If not, he will try using Vitrase to dissolve the Restylane. Will keep you posted and report if the antibiotics help. Fingers crossed!

For those having the periodic swelling of the product, I asked the question to the doctors. Got several answers and one really made sense for me. Since it is swelling about once a month, just prior to my period. The water retention is being pulled to the product. I took some water shedding (over the counter) meds and that worked. All the male doctors had off the wall answers, a female eye doctor had it right and she said it was very common and that some woman just notice it more than others. This swelling is common. Basically, Restylane not the best product around the eyes.

I had restylane one week ago. Had major headache from one week out. Now also getting muscle twitches and heart palpitations. How long will this last should I have it removed. Email me please ****************.***

I spoke to a pharmacist at Midicis Aesthetics about Restylane and Restylane-L.The only diff is the L contains Lidocaine. The ingredients are: Hyaluronic acid is generated by Strep bacteria (Restylane contains gram positive bacterial proteins) NOTE: "Hyaluronan (also called hyaluronic acid or hyaluronate or HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions.[2] One of the chief components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors. The average 70 kg (154 lbs) person has roughly 15 grams of hyaluronan in the body, one-third of which is turned over (degraded and synthesized) every day.[3] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule,[4] and is believed to play a role in virulence.[5][6]" Wiki *The Restylane L contains saline and lidocaine. Both products have the same adverse reactions, or as Medicis calls the reaction, allergic or hypersensitivity reactions, which are nausea and vomiting and headaches, and anaphylaxis (the only reactions that they state as know and expected). So basically what we are likely reacting to is either the Lidocaine or the Strep bacteria proteins, bcuz Hyaluronic acid is found in the body. The definition of a hypersensitivy reaction, which it is specified as the nausea, headaches, vomiting, according to Medicis/Restylane is: Reaction produced by the immune system, which includes allergies AND autoimmunity. It requires a pre-sensitized (immune) state of the host - So I am guessing this means since I had nausea right away with the injection, I was exposed in the past to one of the ingredients and was allergic to it before the injection, (Bacteria or lidocaine), OR that is what they want us to think...What if it causes an autoimmune disease, like gluten causes celiac disease? Consider getting allergy & antibody testing done for the gram positive strep bacteria and maybe lidocaine. FURTHER RESEARCH: The Hyauluronic Acid is chemically modified with unknown added ingredient-CHEMICAL SENSITIVIES? "Native hyaluronan has a relatively short half-life (shown in rabbits) so various manufacturing techniques have been deployed to extend the length of the chain and stabilise the molecule for its use in medical applications. The introduction of protein based cross-links, the introduction of free-radical scavenging molecules such as sorbitol [found in fruits], and minimal stabilisation of the HA chains through chemical agents [!!!] e.g. NASHA stabilisation are all techniques that have been used. Research Due to its high biocompatibility and its common presence in the extracellular matrix of tissues, hyaluronan is gaining popularity as a biomaterial scaffold in tissue engineering research. In particular, a number of research groups have found hyaluronan's properties for tissue engineering and regenerative medicine are significantly improved with crosslinking, producing a hydrogel. This added feature allows a researcher to form a desired shape, as well as to deliver therapeutic molecules, into a host. Hyaluronan can be crosslinked by attaching thiols (trade names: Extracel, HyStem), methacrylates, [PLASTICS] and tyramines (trade name: Corgel) [Tyramine intake has also been associated with MIGRAINE] Hyaluronan can also be crosslinked directly with formaldehyde [POISON] (trade name: Hylan-A) or with divinylsulfone (trade name: Hylan-B) [SYNTHETIC RUBBER]" Wiki

Hi, According to the FDA, Adverse Reactions should be be reported by calling Medicis Aesthetics at 1-866-222-1480. Also review this FDA document regarding antibody testing: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/MedicalDevices/MedicalDevicesAdvisoryCommittee/GeneralandPlasticSurgeryDevicesPanel/UCM252491.pdf