I had the Mixto treatment yesterday afternoon. I took nothing for pain before or after the procedure. Face today is quite red but otherwise no discomfort. There is some pain during the procedure, especially around the eyes and under the nose, but nothing unbearable.
Hopefully redness subsides within a week as I have been told. Improvement was noticeable immediately and should continue as 8-12 weeks is the optimal time to evaluate. Having said that spouse and children both commented that there is already a visible difference in appearance.