Perlane FIller - How Does it Work?

How does perlane work, what is it made form?

Doctor Answers 5


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Hyaluronic Acid Fillers-This is the most popular category of wrinkle fillers. Hyaluronic acid—found naturally in the skin, where it provides moisture, plumpness, firmness, and suppleness to skin—is the ingredient used in these fillers. Since your body produces less hyaluronic acid over time, these fillers can add volume back in the most natural looking way possible. Hyaluronic acid also attracts water to the surface of the skin keeping it fresh and supple. Some research also shows that repeated injections may help stimulate your own production of the skin-firming protein collagen.
There are many different types of hyaluronic acid fillers; each works in a slightly different way with varying results
Perlane is good for more severe facial wrinkles that can benefit from a deeper injection into the skin. Contains the local anesthetic lidocaine to help reduce discomfort during and after the treatment.

New York Dermatologist
4.7 out of 5 stars 11 reviews

What is Perlane?

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Perlane is a clear-gel hyaluronic acid based dermal filler formulated for deeper wrinkles/folds, and has a much larger particle size than Restylane or Juvederm.

Sam Naficy, MD, FACS
Seattle Facial Plastic Surgeon
4.7 out of 5 stars 231 reviews

Perlane is a dermal filler

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Restylane and Perlane are non-allergic, temporary dermal fillers that are more effective and longer lasting than traditional collagen. They are composed of stabilized hyaluronic acid, a natural compound found in all connective tissue. They are injected into wrinkles to fill them and to enhance volume and fill the wrinkle. Restylane and Perlane are the same products, but Perlane has a larger particle size. The choice of product used depends on the characteristics of the skin in the area to be treated.

The most commonly treated areas include glabellar lines (between the eyebrows), nasolabial folds (from the bottom of the nose to the corner of the mouth), lip enhancement and definition, vertical upper lip lines, correcting downturned corner of the mouth, under-eye dark circles, and acne scars. It can also be used for volumer loss in the cheeks and lower face. Results last approximately 6 - 9 months.

Unlike similar products, hyaluronic acid is not produced from animals, so there is virtually no risk of animal or human disease being trans- mitted, or allergic reactions. Restylane and Perlane are similar to Juvederm.

Julia Carroll, MD
Toronto Dermatologist


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Perlane is an FDA approved product that is a dermal filler that adds lost volume and restores youthful contours to the skin to smooth away moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Perlane is composed of hyaluronic acid, a natural substance that already exists in the body. In the human body, natural hyaluronic acid provides volume and fullness to the skin. The hyaluronic acid products have been modified to last longer than the body's hyaluronic acid.


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Perlane is another hyaluronic acid like Restylane and Juvederm. It is a thicker  form than some of these products.    It  may last 6 to 9  months.

Steven Wallach, MD
New York Plastic Surgeon
4.2 out of 5 stars 30 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.