Is it possible for tretinoin (retin-a, renova, etc) to deplete good subcutaneous fat when applied under eye?

I have been using .02mg of renova on the left eye orbital area up to the eyelash margin every night for almost 2 years. I had some fine lines and crows feet that have nearly disappeared with renova. However, I did notice volume loss in the last 2 years particularly around the left tear duct. I rarely applied renova on my right eye (maybe 2x/month) and it seems that fat under my right eye is completely in tact.

No doctor answers yet