How does spironlactone/flutimide taken for acne effect estrogen balance?

I've been alternating with spiro and flutimide for the past few yrs to treat my acne- which it has worked wonders for- and also no oil on my skin or scalp. No breast growth while taking it. My concern is, while my skin is so clear and oil free I'm noticing for the first time signs of aging/fine lines and I want to know if this can be due to my hormonal balance being changed and not having the right balance of estrogen to keep my skin nice while on this drug. Online research is confusing me more!

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