Can DMAE supplements cause Gynecomastia to return after surgery? Can this possiblt affect hormonal balance?

Doctor Answers 4

About Gynecomastia and the Treatment Options

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According to official statistics, 36% of adult young men and 57% of older #adult men in the United States have this medical condition in one of the four grades. 

About 200,000 to 3 million cases of #gynecomastia are being reported every single year. So if you have #breast #enlargement and you feel you're an exception, please understand that 1 in 3 young adult #men and 1 in 2 older adult men are just like you and have breast enlargement. 

Several common factors can cause gynecomastia including excessive levels of #estrogen, natural #hormone changes, use of recreational drugs or alcohol, medications and their associated side effects, and, various health conditions. Also, there are different types of #gynecomastia.

There are three types of surgical #treatment #options available that treat gynecomastia. Your board-certified plastic surgeon will recommend the type best suited for you. The most important decision to be made before performing any surgical procedure is determining whether you are an ideal #candidate. 

Orange County Plastic Surgeon
4.9 out of 5 stars 116 reviews

Gynecomastia re-occuring

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Familial gynecomastia where most of the male breast tissue is removed generally has long lasting results without recurrence as long as your weight remains the same. However, other causes of gynecomastia if still present can cause the residual breast tissue to grow again. For example THC (frequent use of marijuana), certain medications, hormonal imbalance, and other causes can make that happen

DMAE supplements

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Dear foreveryoung908,

Thank you for your clinical post and this is a question that has come up most recently. It is unlikely that the DMAE used in the small amounts found in skin care creams would lead to estrogen/progesterone imbalance that would lead to gynecomastia. Used in very large amounts there is some theoretical risk of this occurring, but is generally impractical when used in the levels found in cosmetic skin care creams. DMAE has been used for well over a decade in some cosmetic skin care lines and gynecomastia has not been a medically reported side effect. However, all things are possible in medicine and if you’re experiencing some gynecomastia and are on DMAE I’d visit with your cosmetic physician or a knowledgeable dermatologist or endocrinologist to decide whether or not to discontinue this product. There are many products that can enhance the skin that do not have gynecomastia as a side effect and you may consider switching regardless.

I hope this information is of some assistance and best of luck. To find out more, please visit the link below.

R. Stephen Mulholland, M.D.
Certified Plastic Surgeon
Yorkville, Toronto

R. Stephen Mulholland, MD
Toronto Plastic Surgeon
4.6 out of 5 stars 101 reviews


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I am not sure anyone can definitely answer this question with certainty.  However, at least in theory, the answer might be possibly/maybe/yes, especially if large applications for prolonged periods occur.  

Jeffrey D. Wagner, MD
Indianapolis Plastic Surgeon
4.9 out of 5 stars 30 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.