Is Osphena effective in relieving pain during sexual intercourse in menopausal women?

Would Osphena be an effective treatment for menopausal women experiencing pain and discomfort during sex?

Doctor Answers 4

Osphena for menopausal symptoms ( vaginal dryness)

Osphena has a selective ( estrogen-like) effect on certain tissues ( endometrium, vagina), which may decrease vaginal dryness and lessen pain during sexual activity. Since Osphena in a pill form passes through the liver, potentially increasing the risk for blood clots, therefore it's not considered the preferred option.  A much safer and established alternative to alleviate vaginal dryness is topical estrogen in many forms ( gel, cream, patch, vaginal preparations ). Both Osphena and estrogen products require additional use of progesterone to prevent an unopposed stimulation of the endometrium ( lining of the uterus), if the uterus is present. To answer your question, Osphena should relieve or reduce pain during sexual activity but there are other, safer options available such as topical estrogen ( in many forms) as well as new, non- hormonal and non-surgical technologies ( laser, radio-frequency). 

Best regards,

Yvonne Wolny, MD

Osphena

Osphena is a drug known as an estrogen agonist/antagonist.  It is similar to tamoxifen or evista which are used in women with breast cancer.  These drugs act like estrogen in some tissue and inhibit it in others.  Osphena has been shown to act like an estrogen in the vaginal tissues so can help women who suffer from vaginal dryness and painful intercourse after menopause.  Unfortunately, it acts like oral estrogen in other areas of the body such as increasing the chance of blood clots.  It also causes hot flashes like tamoxifen so is not tolerated by many women. 

Vaginal estrogen has been proven to be safer than oral estrogens and works well for most women with vaginal changes of menopause.  There are many products available by prescription.  The newest nonhormonal treatments that improve vaginal symptoms are the fractional CO2 lasers, such as Femilift (the first laser available in the US) and MonaLisaTouch. 

Joi Davis, DO
Pewaukee OB/GYN
5.0 out of 5 stars 1 review

Osphena was designed for relieving painful sex in the menopause due to atrophy

Osphena was intended to be an alternative to estrogen for menopausal atrophy related sexual pain. It carries side effects similar to estrogen with an extra side effect - hot flashes - that estrogen doesn't have. As far as how well it works, this varies from woman to woman and you would have to try it out yourself if you were interested. FemiLift offers the same benefits without drugs.

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Osphena

Thank you for your question. Osphena is not an estrogen pill but has ability to modify estrogen receptors. Major action of this medication is to act like estrogen in vulvo-vaginal area. By doing that, Osphena can help with pain and discomfort with intercourse. Unfortunately not everyone is a good candidate for this medication given contraindications and possible side effects. Hope this helps

Armen Kirakosyan, MD, FACOG, FACS
East Aurora Urogynecologist
5.0 out of 5 stars 1 review

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.