Radiesse Vs. Restylane, Which is Best Filler for Lips?

i want to get plumper lips (upper and lower). Is one filler better than another for lip augmentation? What about LiveFill?

Doctor Answers 25

Radiesse is a no-no in the lips.

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The short answer is that Restylane is much better for lip enhancement.

Radiesse (also known as Radiance) is a synthetic filler made from calcium hydroxyapatite, similar to bone. It is injected for soft tissue augmentation and fine lines and wrinkles. Using Radiesse in the lips is asking for trouble as it comes with a high risk for lumps and bumps (granulomas).

If someone wants to inject Radiesse into your lips, I suggest you smile politely, say no thank you, and then run (don't walk) the other way.

Beverly Hills Oculoplastic Surgeon

Juvederm vs LiveFill for lip augmentation

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Radiesse is not FDA approved for injection in the lips. It is a hydroxyapatite, a bone-like material, based. The FDA approval it did receive was with conditions, and for the nasolabial folds. Dissenting members of the FDA commission noted that after its approval, doctors would most likely start using it for unapproved "off-label" uses, such as the lips, which by your question has obviously already occurred. Extreme pain on injection, lumpiness and granuloma formation (permanent lumps) are the usual problems with Radiesse.

Restylane is made of hyaluronic acid and is a fine lip filler. I personally prefer Juvederm or Perlane for temporary filling of the lips (usual duration 4-6 months). They tend to be more supple for lip tissue and less "clumpy" than Restylane.

For patients wishing more permanent lip augmentation, we like our technique of LiveFill (autologous nontraumatized fat-fascial grafts). The disadvantage of LiveFill lip augmentation is the small numbers of doctors performing this technique, the necessity and expense of having an outpatient procedue. Advantages include permanent results, reduction in lip lines, no changes over time as filler wears off, and a high published safety profile.

I personally avoid all semi-permanent fillers in the face because of the chance of chronic inflammation, granuloma formation and lumpiness.

Brent Moelleken, MD
Beverly Hills Plastic Surgeon
4.9 out of 5 stars 195 reviews

Longlasting lip fillers with Juvederm - Los Angeles

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Juvederm is an excellent longlasting filler for the lips. I recently saw a patient who reported that the Juvederm lasted over 18 months since her last visit. Raffy Karamanoukian, Los Angeles

Raffy Karamanoukian, MD, FACS
Los Angeles Plastic Surgeon
4.8 out of 5 stars 95 reviews

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Radiesse should not be used on lips

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Radiesse should not be used in the lips. It uses calcium hydroxypatite to stimulate collagen production, and while it can work very well for reducing nasolabial folds, contouring the face and filling the backs of the hands it has a high risk of nodule formation in the lips and cannot be reversed. For lip augmentation, the best choices are hyaluronic acid fillers such as Restylane or Juvederm. These add instant volume to the lips and if you do not like the results you have options such as reversing it with hyaluronidase. When thinking about having lip fillers, it is extremely important to visit a skilled, board-certified injector who knows the best types of fillers for the lips and has good technique.

Mitchel P. Goldman, MD
San Diego Dermatologic Surgeon
4.9 out of 5 stars 26 reviews

Restylane and Juvederm As the Best Filler For Lips in Augmentation Procedures

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The best fillers for lips would include Juvederm and Restylane. Both are made of lab derived hyaluronic acid, which is a compound already found in our bodies. Not only does hyaluronic acid create volume, but it also has a high capacity for water molecules which hydrates the skin for a more supple and natural look. The main difference between Juvederm and Restylane is in their consistency, with Restylane being the thicker of the two. Radiesse should not be used in the lips. It is a calcium based compound that is better for issues that require filling as well as some degree of structural support. Live Fill is a type of fat transfer. Fat transfer is also not the best option for the lips. Since the lips do move a lot, a good portion of the fat graft is likely to be reabsorbed by the body.

Sanusi Umar, MD
Redondo Beach Dermatologic Surgeon
4.6 out of 5 stars 33 reviews

Do Not Use Radiesse in Lips

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Radiesse is composed of  calcium hydroxyapatite, a white pasty material. It is NOT recommended for lip augmentation as it is prone to nodules when injected into lips which are mostly muscle. Hyaluronic Acid fillers (HA) such as Restylane and Jeuvederm are great for lip augmentation but have to be repeated every 1-2 years as are absorbable. Fat transfer is a good alternative and long lasting

Restylane or Juvederm filler for lips

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Restylane or Juvederm should be used for lip augmentation.  Radiesse should not be used in the lips since it can cause bumps.

Martie Gidon, MD, FRCPC
Toronto Dermatologist

Lip Augmentation Fillers

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Restylane has received FDA approval for lip augmentation.  Juvederm is another good option. Radiesse is not appropriate for the lips as it can easily create a lumpy look.

Kris M. Reddy, MD, FACS
West Palm Beach Plastic Surgeon
4.5 out of 5 stars 56 reviews

Radiesse is not a choice for lip augmentation

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The lip can be augmented with biologic tissue fillers (Restylane, collagen, alloderm), or soft synthetic implants (Advanta, SoftForm, Gor-tex).

Biologic tissue fillers such as Restylane and Alloderm are absorbable. Restylane is distributed by Medicis Aesthetics (now known as Medicis-Inamed) and is made from a component of naturally occurring joint fluid. Alloderm is a skin derivative. Restylane lasts several months to a year, and alloderm lasts one to two years. We do not favor collagen as it is absorbed relatively quickly and some patients have developed reactions to it.

Implants such as Advanta and Gor-tex are permanent. However, some patients don't choose them because they don't like the fact that they will 'feel' the implant. Of the implants, the Advanta implant is preferable and has a high patient satisfaction rate because it is very soft.

Ricardo L. Rodriguez, MD
Baltimore Plastic Surgeon
4.5 out of 5 stars 98 reviews

Lip Fillers

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Radiesse is generally not recommended for lip enhancement as it is white in color and cannot be removed.  Hyaluronic acid fillers such as Restylane, Perlane and Juvederm are better filler choices for the lips.
Best of luck to you!


Philip Young, MD
Bellevue Facial Plastic Surgeon

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.