Is Perlane a Hyaluronic Acid or Something Else?

Doctor Answers 7

Is Perlane a Hyaluronic Acid?

Yes, Perlane is a filler made by the same company that makes Dysport and Restylane. Dysport is a botulinum agent like Botox, and Restylane is also a hyaluronic acid. Fillers can be used to treat different facial folds and wrinkles bases on the size and thickness of the product.  For example, Restylane is very thin and is great for fine lines and around the eyes. Juvaderm and Perlane are thicker and therefore used more for the nasolabial folds and lips.  This varies by doctor and their comfort level with the products.  Hope this helps.

Jacksonville Plastic Surgeon
4.9 out of 5 stars 32 reviews

Is Perlane a Hyaluronic Acid or Something Else?

 Yes Perlane is a hyaluronic acid but it is a thicker filler and is meant to be injected into fatty layers...this means it is not appropriate for the lips and thin lower eyelid skin.  Hope this helps.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 24 reviews

Perlane is the thickest HA of them all.

Perlane is a Medicis product in the Restylane family. It is composed of larger particles with more crosslinking than Restylane making it the ideal Hyaluronic to place deeper into the tissue for those deeper folds and volume loss. I use specifically under deep wrinkles on the face and volume loss over the cheeks and in the temple hollows.  Restlyane by contrast flows better and is preferable in the lips, thinner lines, layering over deep placement of Perlane and for careful placement around the eyes.

Steven Swengel, MD
Los Gatos Dermatologic Surgeon
5.0 out of 5 stars 11 reviews

Perlane is hyaluronic acid

Yes Perlane is a hyaluronic acid but it is a thicker filler and is meant to be injected into areas needing deeper correction and more volume replacement   It really is just a thicker version of Restylane and I've always thought a much better and less confusing name would be Restylane Plus.

Charles E. Crutchfield III, MD
Minneapolis Dermatologic Surgeon
4.3 out of 5 stars 15 reviews

Yes, Perlane is a gel formulation of hyaluronic acid

Yes, Perlane is a clear gel formulation of hyaluronic acid that restores volume and fullness to correct moderate to severe wrinkles and folds such as the nasolabial folds.  Perlane is often the best choice for deep wrinkles because it is made up of large particles that can be injected deeper into the skin.  For most patients, perlane injections last up to 9 months.  Other hyaluronic acids include Restylane and Juvederm.


Paul L. Leong, MD, FACS
Pittsburgh Facial Plastic Surgeon
4.9 out of 5 stars 46 reviews


Perlane is comprised of biotechnologically engineered, non-immunogenic, stabilized hyaluronic acid gel particles. Hyaluronic acid is a natural substance found in all living organisms and provides volume and fullness to the skin. The three-dimensional gel particles in Perlane are hydrophilic molecules, attracting and binding to water molecules as they degrade, helping to maintain volume augmentation for about six months.

Dennis Gross, MD
New York Dermatologist
4.4 out of 5 stars 5 reviews

Perlane is a thicker hyaluronic acid filler

Perlane is made by Medicis which is the same company that makes Restylane. It is a thick hyaluronic acid filler that is excellent for deeper nasolabial fold wrinkles. Hyaluronidase is a liquid that is injected to dissolve injections of hyaluronic acid like Restylane, Juvederm, or Perlane.

Michele S. Green, MD
New York Dermatologist
5.0 out of 5 stars 76 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.