Time Botox takes affect Vs time it takes to wear off?

Is there any correlation between the time Botox takes affect and the time it takes to wear off? If Botox is still taking effect up to three weeks after injections does it mean it is most likely to take longer to wear off? Thank you

Doctor Answers 23

Botox Results

Great question! Although some patients see results sooner, most people report Botox taking effect anywhere between 7-10 days after being injected. Everyone metabolizes Botox differently, however the large majority of patients are able to enjoy the results of Botox for anywhere from 2-4 months. The rate at which you begin to see results does not give us any indication as to how long Botox will last for you. Good luck!

Beverly Hills Facial Plastic Surgeon
4.0 out of 5 stars 7 reviews


Thank you for your question.  Botox can take 10-14 days to take its full effect and can last from 3-6 months.  It is very variable and you can't really predict where in the spectrum each patient will fall.  But if it takes longer to take effect, that doesn't mean that it will last longer.

Jessica Lattman, MD
New York Oculoplastic Surgeon
5.0 out of 5 stars 26 reviews

Botox is variable

BOTOX is variable.  It can take up to 10-14 days to get the final result.  Duration of action often depends upon how much is injected and which muscles it's injected into.  Botox will not last longer just based on the fact it took longer to achieve the full effect.

Joseph A. Eviatar, MD, FACS
New York Oculoplastic Surgeon
4.8 out of 5 stars 62 reviews

Botox Effect and Duration

Great Question. Botox typically takes effect in 5-7 days. It lasts between 3-4 months. At 3 weeks your Botox has likely worked to its full efficacy. There is no correlation between onset of action of the Botox and the time it takes to stop working.

Michael Hromadka, MD
Kalispell Physician
5.0 out of 5 stars 4 reviews


I am not aware of any correlation.  Botox can take a maximum of 2 weeks for the full effects to be seen.  It can last 3-4 months.  The longevity varies from person to person.

Jennifer Trent, MD, FAAD
Sarasota Dermatologic Surgeon
5.0 out of 5 stars 4 reviews

Time Botox takes affect Vs time it takes to wear off?

Thank you for your question.  Botox can take effect as soon as 48 hours, but for most people it will take 7-10 days.  By 14 days one should have full effect.  The time of duration and how long to wear off is also a range.  There have not been any studies to correlate speed of onset to speed of resolution.  Most patients will have an effect that lasts 2-4 months and some as long as 8 months.  

David J. Wages, MD
Peabody Plastic Surgeon
5.0 out of 5 stars 18 reviews

Botox- How long will it last?

Every patient reacts differently to Botox injections. Some people see results after 2 - 3 days, and some notice a  difference after the full 2 weeks. Results will vary from patient to patient- typically results should last 3 0 4 months. I don't believe there is any correlation between time it takes to see results and Botox longevity.

Botox onset and duration of results

Great question. Patient typically start seeing some effect after 48-72 hours. It usually takes 7-14 days for FULL effect to show. The effect of Botox then last 3-4 months in a majority of patients. I do not know of any correlation between time to onset and duration of onset.


Botox will typically take 1-2 weeks for full effect. It will last about 3-4 months depending on the area.

Donald B. Yoo, MD
Beverly Hills Facial Plastic Surgeon
5.0 out of 5 stars 45 reviews

Botox onset versus duration

Dear NellyN: Good physiologic question. As others have mentioned: 1.    Botox onset is 5 to 7 days. 2.    Botox peaks at 10 to 14 days 3.    Botox duration averages 3 months The physiology behind Botox and other neuromodulators such as Dysport and Xeomin is: 1.    Each molecule is the same but made differently by the different manufacturers. This will vary the onset, peak and duration of the prepared vial of medicine 2.    The molecule of botulinum toxin injected into the area of the presynaptic nerve end is broken down by enzymes in the interstitial space within an hour if the Botox does not attached to the nerve cell membrane receptor and  stimulate synaptic absorption into the nerve ending. There are many reasons this can be prolonged or shortened depending on amount and strength of medicine and dilution, amount of enzyme available, concentration of cell membrane receptors, muscle activity and more.  3.    Once in the nerve end, a series of reactions occur for the Botox molecule to act in blocking the delivery of the neurotransmitter acetylcholine out of the nerve end, across the interstitial space without enzymatic breakdown, finding a muscle receptor and stimulation of muscle fibril contraction.  Each step of the way is affected by many different factors in each patient.  4.    The more nerve ends "blocked" by Botox, the denser the inability for muscle contracture and the less movement of the injected muscle and therefore less wrinkling. Other than the above noted averages, there is no answer as to whether late onset means late or early duration.  I hope this helps. All the best!

Dean P. Kane, MD, FACS
Baltimore Plastic Surgeon
4.8 out of 5 stars 69 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.