Is it possible to develop antibodies to Hyaluronidase so that it no longer works?
Doctor Answers 2
I use Hyaluronidase frequently and it would be extremely rare with these small doses to have antibodies to it that would cause it to be ineffective. I would recommend a consult with an expert in Juvederm so that Hyaluronidase is not a concern. Best, Dr Green
Antibodies To Hyaluronidase Possible But Rare With Aesthetic Uses
I so sorry you are having this difficulty. The medical literature does confirm that antibodies to hyaluronidase can develop. However, given its extensive use, not just in aesthetic medicine, but in other medical fields where it is used in even larger doses, it is probably not common at all. And, it would be still more unlikely given the tiny amounts typically used to dissolve hyaluronic acid injectables in aesthetic medicine. That having been said, clearly you have received sixteen treatments, which could have facilitated the development of antibodies and could account for the enzyme's apparent lack of effectiveness in your case. Keep in mind, as well, that Voluma is a hardier injectable, and more resistant to enzymatic and physical breakdown, which is why it is so popular for use in cheeks, etc. and why it lasts so relatively long. It is also possible that you may have developed granulomas in certain locations that are responsible for the bumps you complain of. You might want to consider a second opinion by a board certified aesthetic physician who might, depending upon his/her evaluation, suggest the additional or alternative use of saline injections, subcision, or antiinflammatory injections (and possibly oral antibiotics) to help break up and deal with he troubling residual nodules. Wishing you the best of luck.