Can Radiesse be safely used in smile lines?

Doctor Answers 16

Lots of Safety Data for Radiesse

Radiesse is FDA approved for the nasolabial folds (between your nose and mouth) and that means that it was found to be safe and effective in that area.  It has been safely used for many years in that area.  It would feel very comfortable about using it in that area, if that is what you are calling the "smile lines".  Sometimes, people call the small radial cheek lines of the face "smile lines".  If that is what you are talking about, I would recommend a smoother filler like Belotero, which integrates into the more superficial layers of the skin better, and is made by the same company as Radiesse, called Merz.

Philadelphia Facial Plastic Surgeon
5.0 out of 5 stars 20 reviews

RADIESSE® can be used to safely treat smile lines.

Since RADIESSE® does not dissolve once injected like some hyaluronic acid fillers, it’s especially important to have it administered by a qualified plastic surgeon. An experienced plastic surgeon will assess the depth of your facial lines and help you determine whether they would most likely respond best to RADIESSE® or to other fillers such as Restylane®. Administering RADIESSE® to the smile lines must be done with great care in order to achieve natural-looking results.  

Lee B. Daniel, MD
Eugene Plastic Surgeon
4.7 out of 5 stars 16 reviews

Can Radiesse be safely used in smile lines?

Radiesse is FDA approved for the nasolabial folds (between your nose and mouth). It can be used safely in the smile lines. However, I prefer to use Restylane or Belotero in this area as they are thinner fillers. I recommend having a consultation with an expert. 

Hardik Soni, MD
Summit Emergency Medicine Physician
5.0 out of 5 stars 30 reviews

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Radiesse for smile lines?

While radiesse is possible to be used for the smile lines, there may be better alternatives. Consult with an experienced and expert physician injector to understand your options.

Kris M. Reddy, MD, FACS
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Radiesse for Smile Lines

Radiesse is an excellent stimulatory filler that enhances collagen production over time and it is safely used on the tissues of the face to restore facial harmony and counteract the effects of aging. It is optimal for deeper lines and volume loss correction, so Radiesse is great for the area of smile lines, its effects may last up to 18 months. I use this in my practice for facial contouring and rejuvenation as well. Thank you for your question. 

Edward E. Dickerson, IV, MD
Fayetteville Facial Plastic Surgeon
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Radiesse and smile lines


Radiesse is one of the  many fillers that we use to soften the smile lines. It is a great tool for deeper folds more so than fine creases, and also works great in cheeks, chins,temples, and hands (off label). Is is very safe for use when injected by an experienced physician.

Warm regards,

Dr. Pedy Ganchi                                                                                                                                                          Village Plastic Surgery

Pedy Ganchi, MD
Ridgewood Plastic Surgeon
4.9 out of 5 stars 77 reviews

Can Radiesse be safely used in smile lines?

 Hi, I've performed many dermal filler treatments over the past 30 years.  yes, Radiesse can be used in the smile lines (nasolabial folds) but I prefer using Restylane Lyft which has less lumpiness and skin irritation immediately following injection.

Hope this helps.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 24 reviews


Radiesse is a great option to use to help fill the Nasolabial folds and to sculpt different areas of the face.  It typically lasts one year to a year and a half.  I would make an appointment with a doctor that is experienced with injecting Radiesse to see if it is an option for you.

Can Radiesse be safely used for smile lines?

Radiesse is comprised of Calcium Hydroxylapatite (CaHA) microspheres which can provide immediate volume correction, and continues to work by stimulating the body to produce its own natural collagen. Overtime the body metabolizes the CaHA  and therefore it is still considered as a temporary filler even though it is "irreversible." If you are having fillers for the first time consider "reversible fillers" such as Juvederm or Restylane  which are comprised of Hyaluronic acid. I believe replacing the mid face volume should be done prior to nasolabial correction to avoid unnatural appearance. 

Best of luck

Dr. Shanthala

Radiesse Can Be Used In Smile Lines; But Today Experienced Injectors Contour The Face & Don't Simply Chase After Lines

The short answer to your question is that Radiesse, a natural, calcium-based volumizing filler, can most certainly be used, and has been, to fill smile lines. In fact, I personally began using it for this purpose well over fifteen years ago, at a time when it was called Radiance. It is an excellent injectable volumizer whose main drawback is that there is no specific enzyme or substance available to dissolve it should there be some complication following injection or if the result is not entirely satisfactory. Having said that, I should emphasize that we have come a long way since the early introduction of Radiesse, and nowadays, experienced injectors (not cut-rate medspas and novice injectors of all stripes) rarely jump to treating the smile lines (aka laugh lines, nasolabial folds) without first evaluating the contours of entire face and more often than not addressing the loss of volume in the cheeks and mid-face regions, which are really responsible for the formation of the smile lines in the first place. In fact, sometimes directly treating the smile lines can lead to a chipmunk like look by pushing the cheeks up unnaturally, or if too aggressively injected to the point of flattening the smile lines entirely may give rise to the expressionless monkey face, known as the "simian facies."  Without knowing more about your particular case or having the benefit of photos, I can only speak generally that very often merely by reflating the volume in the cheeks and mid-cheek regions we can secondarily achieve significant improvement in the smile lines without even injecting them directly at all. You would do well to make sure you consult with and are treated by a board certified aesthetic physician with experience and expertise in nonsurgical facial contouring with fillers. Make certain to ask to see his/her before and after photos before agreeing to proceed. Best of luck. 

Nelson Lee Novick, MD
New York Dermatologic Surgeon
4.8 out of 5 stars 26 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.