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Will using the dapsone (Aczone) decrease the effectiveness of my tretinoin 0.05% cream(Retin-A) if both are used nightly?(photo)

Jinx_Dec 9, 2014
Just curious- I've heard various topical products should not be used together for a variety of reasons... usually due to increased irritation. Fortunately, I haven't experienced irritation using both the Aczone & Retin-A nightly as prescribed, but I was wondering if there are any interactions between the two. Could one possibly decrease the potency of the other (similar to how AHA/BHA can reduce the effectiveness of tretinoin if used together) ? Thanks in advance, & take care!

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Hratch Karamanoukian, MD, FACS

The amount of skin laxity that you provide in the picture is not concerning and may be normal.I don't believe that retinoid creams will help change that. There is slight tightening of the skin with routine use of retinoids. 

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Elizabeth Morgan, MD, PhD (closed)

Thank you for your question about your acne treatment.Aczone increases sensitivity of the skin to sun light.So yes, always wear a sun block when using Aczone.Always see a Board Certified Plastic Surgeon.Hope you find this information helpful Best wishes.

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Elizabeth Morgan, MD, PhD (closed)

Thank you for your question about your acne.Retin A takes about 6 weeks to work.The first few weeks things look worse - eventually they should look better.Always see a Board Certified Plastic Surgeon.Hope you find this information helpful Best wishes.

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