How Exactly Does MiraDry Work? What Makes It More Permanent Than Botox?

 MiraDry is suppose to e a more permanent treatment than Botox injections and wondering how it works? What's different about this treatment that makes it more permanent?

Doctor Answers 8


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Although miraDry is getting a lot of attention recently, it has actually been around for a while. It has been extensively studied and there is no cancer association. The FDA has cleared it for safe use as well. The microwave energy only penetrates 4-5mm in depth and heats up and destroys the sweat and odor glands. The energy does not reach lymph nodes or deeper structures and it in non-ionizing radiation (the safe kind, like radiowaves). I have had the procedure done myself and it has truly been a gift. One and done for 80% of people! In the long term, much more cost-effective than Botox which has to be repeated every 3-6 months. Let us know if we can help in any way.
Botox can be a good alternative while miradry is being approved for use in those areas. Botox prevents the nerves from telling the sweat glands to produce sweat and odor. Hope that helps!
And we are the busiest miraDry practice in California with great results.  Let us know if you can help in any way.

Miradry is an excellent treatment

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I have co-authored a book on Miradry that explains the ins and outs of the treatment. Miradry uses microwave energy to destroy the abnormal sweat glands in your armpit. 

Dr. Karamanoukian 
Los Angeles

MiraDry is long lasting, and meant to be permanent

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miraDry works by electomagnetic energy
Botox temporarily binds to the receptors that makes you 
sweat, whilst miraDry destroys the sweat glands themselves.

Dr Davin Lim Cosmetic and Laser Dermatologist

MiraDry is long lasting

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MiraDry is the only FDA-approved procedure that offers long-lasting results.  Studies demonstrate that miraDry results last up to 2 years and are likely permanent as sweat glands do not regenerate.  Botox, on the other hand, typically lasts between 4 and 6 months with the effects wearing off near the end of that time frame.  MiraDry is able to last longer than Botox because miraDry and Botox have different mechanisms of action.  Botox injections temporarily diminish the firing of the nerves that control sweat gland function while miraDry eliminates sweat glands altogether through a novel microwave technology.  Specifically, miraDry utilizes microwave technology to selectively target and eliminate sweat glands in the armpits by focusing electromagnetic waves at a specific level in the body where sweat glands are located.

Botox and miraDry for axillary hyperhidrosis

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Botox block nerves from activating eccrine and presumably apocrine and apoeccrine sweat glands and the effect lasts as long as the Botox is not metabolized or degraded. miraDry uses thermal microwave energy to destroy the sweat glands.

MiraDry destroys sweat glands; botox temporarily inactivates the nerves that cause sweating

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miraDry uses microwave technology to physically destroy and disrupt sweat glands.  Botox works by temporarily disabling the nervous system's ability to communicate with the sweat glands.

Miradry is long term to permanent, botox lasts 6-9 months

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Botox decreases the pumping of the sweat through the sweat glands.  Miradry selectively heats the sweat glands thereby destroying a majority of them.  This translates into permanency of the results in most people.

Cameron Rokhsar, MD, FAAD
New York Dermatologic Surgeon

We eliminate the sweat glands

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Botox inactivates the tiny sweat gland muscles for a period of time.  Miradry actually destroys the sweat glands in the armpit, which is 2% of all your body's sweat glands.  Sweat glands do not regenerate, so by eliminating them the effect is permanent.  There is no danger in getting rid of these 2% of all your sweat glands.

Laura E. Skellchock, MD (in memoriam)
Boca Raton Dermatologic Surgeon

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.