Currently JeNu has two applications, an eye cream with retinol and a lip plumper. The effect on lines in the skin above the lip will probably not be as effective as injections or laser peels, and the line from the corner of the mouth usually requires something like that as well. Another alternative is focused ultrasound with Ultherapy, which is a different procedure even though it also uses ultrasound. Do not use Jenu with products other than the ones that it comes with. JeNu is a very effective device when used for the right purposes.