Impact of Moisturizer on Effectiveness of Hydroquinone and Retin-A Micro?

Does applying a thick moisturizer such as Hydrolatum over an application of Hydroquinone 4% and Retin-A Micro .04% impact the effectiveness of the Hydroquinone and Retin-A Micro? I mix the Hydroquinone and Retin-A Micro together, apply it, wait 20 minutes and then apply a thick layer of the Hydrolatum. Hydro is extremely thick, gooey and dense.

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