Hyalase to Dissolve Juvederm Does Not Seem to Work.

6 weeks ago I had one syringe of Juvederm Ultra to build the cheek area. I did not like the results-over inflated cheeks and uneven / heavy cheek bones. I asked the same doctor to have it all removed. The same doctor has attempted to dissolve with Hyalase, the first time was two weeks ago and the second attempt one week ago. I cannot see a difference. I did not think .4ml of Juv in ea cheek would prove so difficult to dissolve. I have read that you see results in 2/3 days.

Doctor Answers 9

Dissolving Juvederm

It may take multiple injections of hyaluronidase to dissolve the Juvederm. I respectfully suggest you be patient  - .4cc of Juvederm in each cheek should not make that much difference that you look abnormal.

Beverly Hills Facial Plastic Surgeon
4.9 out of 5 stars 39 reviews

Dissolving Juvederm

The full effects of the hyaluronidase should been seen in three days, the treating physician may not have used enough in the treated area to dissolve the product fully or you may need more than one treatment for a large area like the cheeks.

Michele S. Green, MD
New York Dermatologist
5.0 out of 5 stars 78 reviews

Dissolving Juvederm in cheeks


Dissolving Juvederm with Hyaluronidase is generally not difficult...especially such a small amount.  One syringe of Juvederm is not a significant amount of product to use in cheek augmentation, so if you still appear over-inflated after hyaluronidase injections then you may likely have swelling or even some deep bruising that is causing the area to distend.  If the product that was used in your cheeks was not Juvederm however but something like Radiesse, then hyaluronidase will have no effect.  If you did not have a sufficient amount of hyaluronidase injected then you may need more for it to be effective.  Avoid massaging the area to vigorously because you may create more swelling that will make your cheeks appear puffy.

Good luck~

Dr. Grant Stevens

Grant Stevens, MD
Los Angeles Plastic Surgeon
4.7 out of 5 stars 147 reviews

Dissolving Juvederm

Dissolving Juvederm should not be very difficult. Two things are possible. One is that not enough hyaluronidase was used and the second is thatyou might have some swelling. Avoid rubbing on the areas 
(if you are trying to smooth it out) and give it a couple of weeks before you do anything else. Relax, it can be fixed. 

Jo Herzog, MD
Birmingham Dermatologist
5.0 out of 5 stars 19 reviews

Hyaluronidase to Dissolve Juvederm

It may take more than 2 treatments to dissolve Juvederm especially if the product was spread out over a large area such as your cheek.  Please return to your injector for at least one more Hyaluronidase treatment.  Hopefully your injector is skilled in injecting as well as treating unwanted side effects.  The good and the bad with Juvederm is that it will go away on its own so the results will not be permanent.

Sheri G. Feldman, MD
Beverly Hills Dermatologist
5.0 out of 5 stars 1 review

See another physician

It does sometimes take 2-3 sessions to fully dissolve HA fillers, but you should definitely see some progress, especially after 2 treatments with hyaluronidase. If you aren't seeing anything I would recommend you see another physician for a consultation and/or possible treatment.

F. Victor Rueckl, MD
Las Vegas Dermatologist
4.6 out of 5 stars 17 reviews

Juvederm and dissolving

Usually hyaluronic acids dissolve very easily with hyaluronidase.  Maybe it needs to be repeated or the dosing was off?

Steven Wallach, MD
New York Plastic Surgeon
4.1 out of 5 stars 29 reviews

Juvederm Broken Down By Hylauronidase

If the hyaluronidase did not successfully break down the product, it is difficult to determine if this is permanent or not. Generally, Juvederm Ultra Plus XC lasts for approximately 9-12 months, so I would recommend waiting at least this amount of time as it may just take longer for your body to break the product down on its own.

Jerome Edelstein, MD
Toronto Plastic Surgeon
5.0 out of 5 stars 179 reviews

Juvederm and hyaluronidase

If the hyaluronidase did not sting when it was injected, it was not fresh and will not be effective.

Martie Gidon, MD, FRCPC
Toronto Dermatologist
5.0 out of 5 stars 22 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.