What is the Difference Between Centrifuged Fat vs. Fat Mixed with PRP?

what is the difference between centrifuged fat vs fat mixed with PRP (platelet rich plasma). Is it true the latter decreases risk of fat embolism? what can a surgeon do to help prevent fat embolisms?

Doctor Answers 2

Centrifugation vs. PRP

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Centrifugation is the process of spinning the harvested fat in a centrifuge to separate out the blood, serum and other cellular debris from the useful fat.  It takes a while to do this, but is a well-proven method.

Platelet-rich Plasma (PRP) is thought by some surgeons to improve the "take" of the fat, regardless of whether it was centrifuged or not - but this is unproven.

There is no evidence I'm aware of that shows that fat embolism syndrome is reduced by adding PRP to the fat.  It's more about the injection techniques - blunt-tip cannulas, retrograde injection, and micro-injection methods - that help to reduce the chance of fat embolism.


All the best,

What is the Difference Between Centrifuged Fat vs. Fat Mixed with PRP

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Centrifuged fat is fat that is harvested from your belly or thigh and spun down in a centrifuge.  This separates the fat out into its components of pure fat, oil, and ambient liquid and a small amount of blood.  This provides the purest type of fat for injection without a lot of extra debris, and more importantly when injected is relatively precise, meaning you are not overshooting or undershooting.  Fat is typically also micronized or passed in between smaller and smaller syringes so that the individual fat has more ability to be placed in a smooth and natural manner and retain a natural look.  The addition of PRP to this process is believed to enhance the survival of the fat transfer and even increase its ability to proliferate.  Thus providing you a longer lasting and more predictable outcome.  Typically PRP is added after fat is centrifuged as described above.  Call it the icing on the cake.  Hope that helps!

Shepherd G. Pryor, MD
Scottsdale Facial Plastic Surgeon
4.6 out of 5 stars 23 reviews

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