Enzyme or Dissolve Naturally?

Will juvederm and Belotero dissolve more evenly with time vs. hyaluronidase? Thanks.

Doctor Answers 11

Enzyme or dissolve naturally?

In either situation, the filler will dissolve. If you wish to dissolve the filler more quickly, it can be eliminated with hyaluronidase. This can be performed if you are not satisfied with your result. Thank you for the question, and good luck to you. 

Beverly Hills Facial Plastic Surgeon
4.7 out of 5 stars 47 reviews


With time (9-12 months) the products should dissolve completely and evenly.  In the right hands, hyaluronidase can be used to even out lumpy areas, but you may need more filler as well.

Why are you asking this question - have you had asymmetrical results? If you post pictures, we can better advise you.


Asif Pirani, MD, FRCS(C)
Toronto Plastic Surgeon
5.0 out of 5 stars 35 reviews

Enzyme or dissolve naturally?

Hyaluronidase is an enzyme that will completely dissolve hyaluronic acid filler. It is best to use hyaluronidase after the following:

1) An undesirable result
2) For quick removal of the product

The filler will dissolve to the same degree following treatment with hyaluronidase or time in general. It is just a matter of whether you desire immediate removal of the product. I hope this help, and I wish you the best of luck.

Jonathan Kulbersh, MD
Charlotte Facial Plastic Surgeon
5.0 out of 5 stars 64 reviews

HA's Which will dissolve more evenly, Enzyme or time?

If either product is injected unevenly it will remain that way until it's gone.  Certainly you can wait it out if you want, but Hyaluronidase carefully and minimally injected can smooth out unwanted or excess product. It's a bit of art and science so choose your provider based upon expertise and talent

Sam Naficy, MD, FACS
Seattle Facial Plastic Surgeon
4.7 out of 5 stars 218 reviews

Hyaluronidase is used to dissolve Hyaluronic acid based injectables.

Hyaluronidase dissolves any of the hyaluronic acid based injectables - which means Juvederm, Restylane, and Belotero.  These hyaluronic acid based fillers all dissolve over time.  Juvederm is a thicker filler and lasts approximately a year in duration and slowly dissolves over time.  Restylane lasts six to nine months and dissolves a little sooner than Juvederm.  Belotero is thinner and meant for the more shallow lines, especially around the mouth and under the eyes.  It lasts approximately six months in duration.  If ever the injections are not to your liking, they can be dissolved with hyaluronidase.  Please find an experienced injector in your area to get the best results.

Michele S. Green, MD
New York Dermatologist
5.0 out of 5 stars 72 reviews

Enzyme or Dissolve Naturally?

     Hyaluronidase can be used if too much product has been used or if it has been injected too superficially or there is irregularity.  Kenneth Hughes, MD Los Angeles, CA

Kenneth B. Hughes, MD
Los Angeles Plastic Surgeon
4.9 out of 5 stars 485 reviews

Enzyme or Dissolve Naturally?

 HA's will eventually go away completely on their own.  Injections of hyaluronidase can dissolve some but not all of the filler.  Unless the rsults are truly unsightly, let the Juvederm and Belotero dissolve on its own.  To achieve the desired aesthetic result when augmenting and shapng the face with fillers requires that the plastic and cosmetic surgeon/MD understand and follow the proper aesthetics of facial beauty for the creation of a naturally more attractive face.

Francis R. Palmer, III, MD
Beverly Hills Facial Plastic Surgeon
4.6 out of 5 stars 24 reviews

Dissolving product

Hyaluronidase will dissolve product quickly and the other products will dissolve slowly over time.

Steven Wallach, MD
New York Plastic Surgeon
4.2 out of 5 stars 26 reviews

Hyaluronidase or dissolve naturally?

Hyaluronidase will dissolve Juvederm and Belotero quickly whereas it would take longer if you were to wait it out for the hyaluronic acid to be absorbed naturally.  So when choosing between enzyme vs time for dissolving the material, it is not so much a matter of how even one way or the other would be, but a matter of your level of satisfaction (could you live with the bump/irregularity for a few months or would you rather have it dealt with right away).  

(This answer is not intended nor implied to be a substitute for medical advice.  It is posted for patients’ general education only.  Always seek the advice of your physician or other qualified healthcare provider for further evaluation of your individual case.) 

Mireille Chae, MD
Seattle Dermatologist
5.0 out of 5 stars 1 review

Hyaluronidase or Dissolve Naturally?

The answer really depends upon your level of concern regarding your filler treatment. If you want a bump or line or excessive fullness resolved now, hyaluronidase is your best, fastest option. If you're concerned about a more subtle issue than time will improve any imperfections in your filler treatment. Hyaluronidase will provide a smooth result when performed by an experienced injector. I hope this information is helpful.

Stephen Weber MD, FACS

Weber Facial Plastic Surgery

Stephen Weber, MD, FACS
Denver Facial Plastic Surgeon
4.9 out of 5 stars 129 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.