Developed a Tolerance for Botox. Will miraDry Still Work?

Doctor Answers 12

MiraDry is still effective with Botox tolerance

Yes, miraDry will still work as Botox and miraDry use different mechanisms.  Botox prevents the nerves from firing. miraDry actually removes te sweat and odor glands.


Santa Monica Dermatologic Surgeon
5.0 out of 5 stars 3 reviews

MiraDry can still work in people that don't respond to botox

miraDry and Botox work by two different mechanisms.  The fact that you no longer respond to Botox is not an indicator of whether you will respond to miraDry.  A small percentage of patients do not respond to miraDry, but the percentage is exceedingly small.

If Botox has stopped working to decrease sweating, MiraDry can be used.

If Botox has stopped working to decrease sweating, MiraDry can be used. These procedures attack sweat glands in entirely different ways. And the results of MiraDry should be permanent.

William P. Coleman III, MD
Metairie Dermatologic Surgeon
3.5 out of 5 stars 2 reviews

Botox vs. miraDry

MiraDry would be a great option for you! As you know from your treatments, Botox is a temporary solution for excessive underarm sweating. With miraDry, in a single treatment, you will experience immediate and permanent reduction to your underarm sweat. Despite having a tolerance to Botox treatments, miraDry will still be effective. MiraDry uses microwave technology to target and eliminate sweat and odor glands of the underarms. Most people are more than satisfied with the reduction from the initial treatment, however, if you would like further reduction you can be choose to have a second treatment 3 months later. At our practice, we do offer a discounted rate for the second treatment, as the vast majority do not need an additional procedure.

MiraDry vs Botox

You are an excellent candidate,mira dry works entirely differently and will be much less money within one to two years
Cost for miraDry Treatment
The first treatment is about 1800-2200 dollars. Some patients may request a second treatment at about 4-6 months which is usually less money. Fees may vary by doctor and geographic location. Check on Real Self for estimated costs in your area or check miraDry.com .

Jed H. Horowitz, MD, FACS
Orange County Plastic Surgeon
5.0 out of 5 stars 69 reviews

Miradry will still work for you!

Although miraDry is getting a lot of attention recently, it has actually been around for a while. It has been extensively studied and there is no cancer association. The FDA has cleared it for safe use as well. The microwave energy only penetrates 4-5mm in depth and heats up and destroys the sweat and odor glands. The energy does not reach lymph nodes or deeper structures and it in non-ionizing radiation (the safe kind, like radiowaves). I have had the procedure done myself and it has truly been a gift. One and done for 80% of people! In the long term, much more cost-effective than Botox which has to be repeated every 3-6 months. Let us know if we can help in any way.
Botox can be a good alternative while miradry is being approved for use in those areas. Botox prevents the nerves from telling the sweat glands to produce sweat and odor. Hope that helps!
And we are the busiest miraDry practice in California with great results. Let us know if you can help in any way.

Sheila S. Nazarian, MD
Beverly Hills Plastic Surgeon
5.0 out of 5 stars 41 reviews

MiraDry vs. Botox

Hi and thank you for your question! miraDry works to destroy the sweat and odor glands, whereas botox will only work on the sweat glands. Also, botox, as you know, will wear off after about 3 months, whereas miraDry is a permanent option for both sweat and odor reduction, eliminating the need for deodorant and anti-perspirant. There should be no issue with Mirday working, even though you’ve developed a tolerance to botox. In addition, MiraDry just received an indication for hair removal also. 70% reduction of all hair colors. For any miraDry questions please call our office for a complimentary consultation with our Nurse Practitioner, Jennifer Tinelli. Thank you!

Grant Stevens, MD
Los Angeles Plastic Surgeon
5.0 out of 5 stars 113 reviews

MiraDry works even if they have built up a tolerance to Botox

Yes, miraDry works for patients who have developed a tolerance to Botox.  This is because miraDry and Botox have different mechanisms of action.  Botox injections temporarily diminish the firing of the nerves that control sweat gland function while miraDry eliminates sweat glands altogether through a novel microwave technology.  Specifically, miraDry utilizes microwave technology to selectively target and eliminate sweat glands in the armpits by focusing electromagnetic waves at a specific level in the body where sweat glands are located.  Botox typically lasts between 4 and 6 months with the effects wearing off near the end of that time frame.  MiraDry is the only FDA-approved procedure that offers long-lasting results.  Studies demonstrate that miraDry results last up to 2 years and are likely permanent as sweat glands do not regenerate.  

Joshua L. Fox, MD
Long Island Dermatologic Surgeon
5.0 out of 5 stars 17 reviews

Tolerance to Botox and effectiveness of miraDry

Developing a tolerance to Botox has nothing to do with how miraDry works. So, the answer to your question is that in your situation, miraDry is the ideal tratment for underarm hyperhidrosis and will prove in the long run to be a less expensive alternative than repeat Botox injections in the underarms. EliminateSweating

Miradry > Botox

Results of Miradry are achieved through a different mechanism than Botox. THerefore, Miradry will still be effective even if Botox won't! 

Cameron Rokhsar, MD, FAAD
New York Dermatologic Surgeon
4.5 out of 5 stars 34 reviews

These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.