I have developed antibodies to Botox after using it for about 6 years. Will Frotox be an alternative for me?
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Doctor Answers 6
Other Neurotoxins Since Botox Isnt Working
Frotox instead of Botox
Frotox is not FDA approved or available in the US. There is no indication yet that it is effective. If you have developed antibodies to Botox I would try Xeomin or Dysport to see if you have better results. Please let me know if the other neuromodulators work better for you.
Hold The Frotox; Xeomin Can Be Effective When Botox and Dysport No Longer Work As Well
I have been using Botox for cosmetic reasons since 1991. Since that time, I occasionally encounter a patient who at first responded well to Botox, but after several treatment sessions, no longer responded as well or has not maintained his/her improvement for as long as previously. Some, for example, who in the past may have enjoyed six months of correction were seeing no more than four to eight weeks of results. I have been using Dysport for over ten years already and have seen a similar phenomenon with this neuromodulator, as well.
One possible explanation that has been proposed for this problem is the development of antibodies to the injectables, although this is considered to be quite rare. Nevertheless, in such cases, I have been switching these patients to Xeomin, a neuromodulator very much like Botox, but whose manufacturer has taken pains to strip all unnecessary excess proteins from the active molecule in order to reduce its potential to provoke antibody formation. So far, I have generally had success with Xeomin in cases where patients have been suspected of antibody formation to the other two approved agents. I definitely believe it is worth a try in these instances.
Frotox, or Coldtox, as it is also known, is enticing, in so far as it seems to be a non-neuromodulator method for temporarily freezing the nerves. It is not available in the U.S., and it has neither yet stood the test of time nor undergone extensive use, and for this reason I would be cautious in embracing or recommending this technology before it has done so.
Consultation with a board certified aesthetic core physician with expertise and extensive experience with all neuromodulators would be strongly advised before embarking on any "next new thing."
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Antibodies to Botox, what can I try instead
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