Hi, Unfortunately Blisters can occur with tattoo laser removal treatments and often they appear further along in your treatment as the settings are cranked up often at subsequent sessions to help better remove the ink. Recommend first call your provider and send them a photo as done here to let them know and get their recommendations and our recommendations go something like this. Unless it is very huge and about to pop, please don't pop it. And, keep it very clean and covered..you can wash it out with soap and water...and no further treatments until completely healed. Usually next tat removal sessions isn't until 4-6 weeks down the road anyway, Again, any questions always call your provider and if continued concerns after the phone call, schedule an appt and go in...we tell clients we are here and prefer they come in versus worrying. Take care, Dr. Amy