How Much Does Hyaluronidase Cost?

Hyaluronidase costs $475 on average, according to 201 reviews by RealSelf members; the price of your unique treatment can range from as little as $150 to as much as $4,006

Hyaluronidase is an injectable enzyme that helps dissolve hyaluronic acid-based dermal fillers. This is done for a variety of reasons:

  • When a patient is dissatisfied with their hyaluronic acid-based dermal filler results. For example, if you don’t like the shape or size of your newly plumped-up lips, a provider can tweak the results or reverse them entirely.
  • Prior to plastic surgery. If you’re having a facial procedure like a rhinoplasty or cheek augmentation, filler should be dissolved ahead of surgery, so it doesn’t affect your surgeon’s ability to operate. 
  • Emergency situations. When filler is mistakenly injected into a blood vessel, it can cause a blockage, which can be extremely dangerous—in some cases, it can lead to tissue death or blindness. Hyaluronidase injections are invaluable in such events. 

Read on to find out why hyaluronidase costs can vary, what’s included in the price, and whether actual patients think their results were worth what they paid.

Related: Everything You Need to Know About Hyaluronidase

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What does the cost of hyaluronidase include?

During your consultation, you’ll discuss your concerns and your provider will estimate how much product they’ll need to use. This is the time to get a personalized hyaluronidase injection cost quote, which should include:

  • Numbing cream 
  • The treatment itself: both the product and the provider’s time performing it
  • Ice packs to help alleviate any discomfort post-procedure

In some cases, you may also receive a complimentary topical pain reliever.

Which factors affect how much hyaluronidase injections cost?

The price of hyaluronidase injections can fluctuate widely, due to: 

1. Who performs your hyaluronidase injections

Hyaluronidase can be administered by a nurse practitioner, physician assistant, or a physician (most often a dermatologist or plastic surgeon). 

It probably won’t surprise you to hear that experienced, board-certified physicians, who have more advanced training than nurses and PAs, will charge more for their time and expertise. 

If you’re seeking out hyaluronidase injections due to complications or poor results, reach out to the provider who performed your initial filler treatment. They may offer hyaluronidase free of charge. However, don’t expect a complimentary appointment if you simply changed your mind. 

2. Their practice location

Just as dermal filler costs vary from location to location, so do hyaluronidase treatments. Expect to pay more for hyaluronidase injections in major metropolitan areas with higher costs of living, especially in a high-rent neighborhood.

3. How much hyaluronidase you need to achieve your desired result

Hyaluronidase injections cost more or less, depending on how much filler you’re hoping to dissolve as well as the specific type of HA filler you’re aiming to undo. More highly cross-linked gels, like Juvéderm Voluma, tend to be more resistant than others; they require a greater dose of hyaluronidase to disconnect the molecule chains. In fact, tenacious fillers often require more than one round of hyaluronidase injections.

Trying to reverse the effects of chin, jaw, or cheek fillers—which took multiple syringes of a sturdy filler to achieve—will likely cost much more than it would to smooth out the appearance of uneven lip injections or dissolve a single lump.

4. The complexity of your treatment

Some areas are more straightforward to inject than others, and treatments that are easier for the provider to perform tend to be more affordable. 

For example, if your provider is administering you hyaluronidase because of under-eye filler gone wrong (especially a situation like vascular occlusion), precision is critical, which may end up raising the cost of hyaluronidase treatment. 

In emergency situations, don’t focus on the price tag: that hyaluronidase injection may save you from serious tissue damage or even blindness.

Is hyaluronidase worth the money?

This treatment has a 45% Worth It Rating from reviewers on RealSelf, so a significant number of people who’ve had hyaluronidase injections don’t think their results were worth the price they paid.

Those who rated the procedure as “Worth It” said that hyaluronidase immediately improved the look of misplaced filler or was an effective solution to dissolve old filler, often in advance of facial plastic surgery.

A majority of those who were unhappy with their results claimed that hyaluronidase injections made them look older.

This is a known risk of treatment with hyaluronidase: the enzyme dissolves any hyaluronic acid—whether it’s in dermal filler or your natural tissue. The good news is that our bodies are constantly replenishing our natural hyaluronic acid. 

If you’re unhappy with your dermal filler, there are no other treatments that compare to hyaluronidase, but as with every procedure, it comes with risk. 

Hyaluronic acid fillers will dissolve on their own over time, so if you’re looking to save money, haven’t experienced any complications, and the cost (and risk) of hyaluronidase seems less tolerable than your results, you may just want to wait it out.

Are hyaluronidase injection costs covered by insurance?

No. The FDA has approved the use of hyaluronidase only to support your body’s absorption of medications administered via injection—not to dissolve dermal filler—so you’ll have to pay out of pocket for this “off-label” cosmetic treatment.

Interested in hyaluronidase?

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Can you finance the cost of hyaluronidase treatment?

Yes, there’s a good chance you’ll be able to finance hyaluronidase injections. 

Talk to your provider to see if they offer a monthly payment plan, or research lenders like CareCredit

Just keep in mind that going this route will end up being more costly in the long run, as you’ll have to pay the principal and interest.