{"id":23794,"date":"2022-11-08T11:36:31","date_gmt":"2022-11-08T19:36:31","guid":{"rendered":"https://www.realself.com\/news\/?p=23794"},"modified":"2022-11-08T11:36:35","modified_gmt":"2022-11-08T19:36:35","slug":"what-is-topilase","status":"publish","type":"post","link":"https://www.realself.com\/news\/what-is-topilase","title":{"rendered":"Topilase Is a Cream That Painlessly Dissolves Filler\u2014and It&#8217;s Coming to the U.S. Soon"},"content":{"rendered":"<?xml encoding=\"utf-8\" ?><p>If you&rsquo;ve been treated with <a href=\"https:\/\/www.realself.com\/nonsurgical\/dermal-fillers\">hyaluronic acid&ndash;based dermal fillers<\/a>, then you might already be familiar with hyaluronidase. Administered via injection, <a href=\"https:\/\/www.realself.com\/nonsurgical\/hyaluronidase\">hyaluronidase<\/a> is a naturally occurring enzyme that breaks down hyaluronic acid (HA)&mdash;giving it the ability to take down the volume of overfilled lips or puffy under-eyes. While your body will eventually metabolize the filler, hyaluronidase speeds up this process for immediate results.<\/p><p>That said, there are some drawbacks: for one, it can be imprecise and can often remove more hyaluronic acid filler than intended, especially in the hands of an inexperienced provider. That&rsquo;s where Topilase, a breakthrough topical form of hyaluronidase, can be helpful.<\/p><p>If you&rsquo;ve never heard of Topilase, you&rsquo;re not alone&mdash;we hadn&rsquo;t either, until recently. Created by French physician <a href=\"https:\/\/www.drsebban.com\/en\/dr-sandrine-sebban\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dr. Sandrine Sebban<\/a>, Topilase, which is manufactured by Softfil, is being used across Europe and Asia to impressive results, but it&rsquo;s not yet available in the United States.<\/p><p>Currently, New York City board-certified facial plastic surgeon <a href=\"https:\/\/www.realself.com\/dr\/yael-halaas-new-york-ny\">Dr. Yael Halaas<\/a>, who serves as the head of the Emerging Trends &amp; Technology committee for the American Academy of Facial Plastic and Reconstructive Surgery, is testing Topilase in her practice. She predicts a demand for it once it arrives, likely beginning in 2023: &ldquo;Patients want a light-handed approach in dealing with imperfect results from filler.&rdquo;<\/p><p>Here&rsquo;s what else you need to know about the innovative product.&nbsp;<\/p><div id=\"doctorCTA_shortcode\" style=\"text-align:center;\"><a class=\"button\" href=\"https:\/\/www.realself.com\/find\" style=\"padding: 15px;margin-top: 0px;margin-bottom: 1.75rem;width: 300px;max-width: 100%;\">Find Doctors Near You<\/a><\/div><h2 class=\"wp-block-heading\" id=\"h-what-is-topilase\">What is Topilase?<\/h2><p>Topilase is a topical solution that contains both hyaluronidase as well as herbal ingredients such as lavender, helichrysum, and aloe vera. It offers a needle-free way to get the hyaluronic acid&ndash;dissolving effects of hyaluronidase&mdash;albeit on a much more subtle level than with the injectable version. &ldquo;It certainly doesn&rsquo;t dissolve all the filler, but it appears to reduce it,&rdquo; Dr. Halaas says.<\/p><h2 class=\"wp-block-heading\" id=\"h-how-is-topilase-used\">How is Topilase used?<\/h2><p>Application is simple: the Topilase formula is applied, then massaged into the treatment area. After several minutes, &ldquo;you can actually see a reduction by a small but appreciable percentage in the overfilled area,&rdquo; Dr. Halaas says.<\/p><center><blockquote class=\"instagram-media\" data-instgrm-captioned=\"\" data-instgrm-permalink=\"https:\/\/www.instagram.com\/reel\/Cj0mMIKjHjG\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\" style=\" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);\"><div style=\"padding:16px;\"> <a href=\"https:\/\/www.instagram.com\/reel\/Cj0mMIKjHjG\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;\" target=\"_blank\" rel=\"noopener\"> <div style=\" display: flex; flex-direction: row; align-items: center;\"> <div style=\"background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 516.623,62.101 C516.479,58.943 516.448,57.996 516.448,50 C516.448,42.003 516.479,41.056 516.623,37.899 C516.755,34.978 517.244,33.391 517.654,32.338 C518.197,30.938 518.846,29.942 519.894,28.894 C520.942,27.846 521.94,27.196 523.338,26.654 C524.393,26.244 525.979,25.756 528.898,25.623 C532.057,25.479 533.004,25.448 541,25.448 C548.997,25.448 549.943,25.479 553.102,25.623 C556.021,25.756 557.607,26.244 558.662,26.654 C560.06,27.196 561.058,27.846 562.106,28.894 C563.154,29.942 563.803,30.938 564.346,32.338 C564.756,33.391 565.244,34.978 565.378,37.899 C565.522,41.056 565.552,42.003 565.552,50 C565.552,57.996 565.522,58.943 565.378,62.101 M570.82,37.631 C570.674,34.438 570.167,32.258 569.425,30.349 C568.659,28.377 567.633,26.702 565.965,25.035 C564.297,23.368 562.623,22.342 560.652,21.575 C558.743,20.834 556.562,20.326 553.369,20.18 C550.169,20.033 549.148,20 541,20 C532.853,20 531.831,20.033 528.631,20.18 C525.438,20.326 523.257,20.834 521.349,21.575 C519.376,22.342 517.703,23.368 516.035,25.035 C514.368,26.702 513.342,28.377 512.574,30.349 C511.834,32.258 511.326,34.438 511.181,37.631 C511.035,40.831 511,41.851 511,50 C511,58.147 511.035,59.17 511.181,62.369 C511.326,65.562 511.834,67.743 512.574,69.651 C513.342,71.625 514.368,73.296 516.035,74.965 C517.703,76.634 519.376,77.658 521.349,78.425 C523.257,79.167 525.438,79.673 528.631,79.82 C531.831,79.965 532.853,80.001 541,80.001 C549.148,80.001 550.169,79.965 553.369,79.82 C556.562,79.673 558.743,79.167 560.652,78.425 C562.623,77.658 564.297,76.634 565.965,74.965 C567.633,73.296 568.659,71.625 569.425,69.651 C570.167,67.743 570.674,65.562 570.82,62.369 C570.966,59.17 571,58.147 571,50 C571,41.851 570.966,40.831 570.82,37.631\"><\/path><\/g><\/g><\/g><\/svg><\/div><div style=\"padding-top: 8px;\"> <div style=\" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;\">View this post on Instagram<\/div><\/div><div style=\"padding: 12.5% 0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div><\/div><\/a><p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\"><a href=\"https:\/\/www.instagram.com\/reel\/Cj0mMIKjHjG\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;\" target=\"_blank\" rel=\"noopener\">A post shared by Dr. Yael Halaas: Science &amp; Beauty (@drhalaas)<\/a><\/p><\/div><\/blockquote> <script async=\"\" src=\"\/\/www.instagram.com\/embed.js\"><\/script><\/center><p>Since the solution remains active for two weeks, the patient can return within that two-week period for up to three applications until they get the desired result. For thin-skinned areas in particular, she says, &ldquo;it can take a result that is slightly overfilled and smooth out some imbalances&mdash;or bring down a result that&rsquo;s slightly too much.&rdquo;<\/p><p>It also shows early promise for reducing swelling. In France, the physician who created it reports using it on patients immediately following injection, according to Dr. Halaas, because the homeopathic botanicals in the formula may help reduce swelling.<\/p><p>While Dr. Halaas doesn&rsquo;t have enough product to test it for this specific purpose, in cases abroad, Topilase has been shown to &ldquo;minimize all swelling after injections,&rdquo; she says. &ldquo;In my practice, I use a number of herbal topicals after to help reduce swelling, so once this is more widely commercially available, this may be something I adopt.&rdquo;<\/p><div class=\"newsletter-signup\" id=\"newsletterForm\">\n    <h2 class=\"newsletter-signup__heading\" id=\"unlock-a-world-of-modern-beauty\">Unlock a world of modern beauty<\/h2>\n    <p class=\"newsletter-signup__text\">Stay up-to-date on trending news, popular procedures, and exclusive content.<\/p>\n    <div class=\"newsletter-signup__wrapper\">\n        <input class=\"newsletter-signup__input\" type=\"email\" id=\"newsletterEmail\" placeholder=\"Enter your email\">\n        <button class=\"newsletter-signup__button button\" onclick=\"submitEmail()\">SUBSCRIBE<\/button>\n    <\/div>\n    <div class=\"newsletter-signup__small\"><p><span style=\"font-weight: 400;\">By subscribing, you accept our <\/span><a href=\"https:\/\/www.realself.com\/real_self_privacy_policy.html\"><span style=\"font-weight: 400;\">Privacy Policy<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.realself.com\/terms-of-service\"><span style=\"font-weight: 400;\">Terms of Service<\/span><\/a><span style=\"font-weight: 400;\"> and agree to receive marketing emails.<\/span><\/p>\n<\/div>\n    <div id=\"newsletter-message\" class=\"newsletter-signup__message\"><\/div>\n<\/div><h2 class=\"wp-block-heading\" id=\"h-topilase-vs-hyaluronidase\">Topilase vs. hyaluronidase<\/h2><p>Topilase isn&rsquo;t a simple swap for injectable hyaluronidase. &ldquo;No topical is going to replace an injection,&rdquo; says Dr. Halaas. &ldquo;If you have a filler emergency, like a vascular obstruction, you must have and be prepared to inject hyaluronidase&mdash;and that emergency protocol is why you need to be injected by a knowledgeable injector.&rdquo;<\/p><p>Plus <a href=\"https:\/\/www.realself.com\/dr\/mona-gohara-danbury-ct\">Dr. Mona Gohara<\/a>, a board-certified dermatologist based in New Haven, Connecticut, expresses skepticism that it would work for deep filler. &ldquo;I do not really understand how something topically could truly affect deep dermal placement of HA filler,&rdquo; she says.<\/p><p>However, therein is the advantage: Topilase may be preferable for certain, more superficial areas of the face. &ldquo;What can be impressive is that with thin-skinned areas, like lips or under-eyes, is that it did appear to reduce the overfilled effect,&rdquo; says Dr. Halaas. Since the skin is inherently thinner, there&rsquo;s a considerable chance that the hyaluronidase can penetrate superficially, thus doing its work.<\/p><h2 class=\"wp-block-heading\" id=\"h-does-topilase-hurt\">Does Topilase hurt?<\/h2><p>Topilase doesn&rsquo;t hurt, which gives it an another edge over injectable hyaluronidase, which can be uncomfortable. &ldquo;Patients sometimes complain about the burning feeling from injectable hyaluronidase,&rdquo; says Dr. Halaas. &ldquo;They want to have a needle-free approach.&rdquo; For certain areas of the face, then, Topilase can offer a much more comfortable alternative.<\/p><h2 class=\"wp-block-heading\" id=\"h-how-much-will-topilase-cost\">How much will Topilase cost?<\/h2><p>As of press time, Prollenium hasn&rsquo;t shared the pricing with providers, so it&rsquo;s unclear what the cost will be for patients once it becomes available.<\/p><div id=\"doctorCTA_shortcode\" style=\"text-align:center;\"><a class=\"button\" href=\"https:\/\/www.realself.com\/find\" style=\"padding: 15px;margin-top: 0px;margin-bottom: 1.75rem;width: 300px;max-width: 100%;\">Find Doctors Near You<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>If you&rsquo;ve been treated with hyaluronic acid&ndash;based dermal fillers, then you might already be familiar with hyaluronidase. Administered via injection, hyaluronidase is a naturally occurring enzyme that breaks down hyaluronic acid (HA)&mdash;giving it the ability to take down the volume of overfilled lips or puffy under-eyes. While your body will eventually metabolize the filler, hyaluronidase [&hellip;]<\/p>\n","protected":false},"author":133,"featured_media":23795,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9075],"tags":[19408],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.0 (Yoast SEO v23.0) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>How Topilase Dissolves Filler vs. Hyaluronidase | RealSelf News<\/title>\n<meta name=\"description\" content=\"Topilase is an innovative topical cream that dissolves excess or unwanted filler without pain or needles. Here&#039;s what you need to know.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https://www.realself.com\/news\/what-is-topilase\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Topilase Is a Cream That Painlessly Dissolves Filler\u2014and It&#039;s Coming to the U.S. Soon\" \/>\n<meta property=\"og:description\" content=\"Topilase is an innovative topical cream that dissolves excess or unwanted filler without pain or needles. 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