{"id":17314,"date":"2020-10-30T14:37:16","date_gmt":"2020-10-30T21:37:16","guid":{"rendered":"https://www.realself.com\/news\/?p=17314"},"modified":"2023-08-25T14:43:19","modified_gmt":"2023-08-25T21:43:19","slug":"xeomin-botox-alternative","status":"publish","type":"post","link":"https://www.realself.com\/news\/xeomin-botox-alternative","title":{"rendered":"The &#8220;Fastest-Growing Neurotoxin&#8221; in the U.S. Markets Itself as \u201cClean.\u201d Docs Reveal What That Actually Means."},"content":{"rendered":"<?xml encoding=\"utf-8\" ?><p>Gwyneth Paltrow&rsquo;s latest beauty recommendation isn&rsquo;t jade eggs or vaginal steams but something even more unexpected. Last month, she became the global face of <a href=\"https:\/\/www.realself.com\/xeomin\">Xeomin<\/a> (pronounced zee-o-min), an injectable wrinkle reducer that she calls a &ldquo;uniquely purified&rdquo; toxin.&nbsp; Coming from the Goop founder&mdash;who&rsquo;s famous for her controversial wellness advice&mdash;the campaign has some people wondering if Xeomin actually does offer a cleaner, purer way to treat frown lines.&nbsp;<\/p><center><blockquote class=\"instagram-media\" data-instgrm-captioned=\"\" data-instgrm-permalink=\"https:\/\/www.instagram.com\/p\/CFPhHchsE_H\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"12\" style=\" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);\"><div style=\"padding:16px;\"> <a href=\"https:\/\/www.instagram.com\/p\/CFPhHchsE_H\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;\" target=\"_blank\" rel=\"noopener noreferrer\"> <div style=\" display: flex; flex-direction: row; align-items: center;\"> <div style=\"background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 516.623,62.101 C516.479,58.943 516.448,57.996 516.448,50 C516.448,42.003 516.479,41.056 516.623,37.899 C516.755,34.978 517.244,33.391 517.654,32.338 C518.197,30.938 518.846,29.942 519.894,28.894 C520.942,27.846 521.94,27.196 523.338,26.654 C524.393,26.244 525.979,25.756 528.898,25.623 C532.057,25.479 533.004,25.448 541,25.448 C548.997,25.448 549.943,25.479 553.102,25.623 C556.021,25.756 557.607,26.244 558.662,26.654 C560.06,27.196 561.058,27.846 562.106,28.894 C563.154,29.942 563.803,30.938 564.346,32.338 C564.756,33.391 565.244,34.978 565.378,37.899 C565.522,41.056 565.552,42.003 565.552,50 C565.552,57.996 565.522,58.943 565.378,62.101 M570.82,37.631 C570.674,34.438 570.167,32.258 569.425,30.349 C568.659,28.377 567.633,26.702 565.965,25.035 C564.297,23.368 562.623,22.342 560.652,21.575 C558.743,20.834 556.562,20.326 553.369,20.18 C550.169,20.033 549.148,20 541,20 C532.853,20 531.831,20.033 528.631,20.18 C525.438,20.326 523.257,20.834 521.349,21.575 C519.376,22.342 517.703,23.368 516.035,25.035 C514.368,26.702 513.342,28.377 512.574,30.349 C511.834,32.258 511.326,34.438 511.181,37.631 C511.035,40.831 511,41.851 511,50 C511,58.147 511.035,59.17 511.181,62.369 C511.326,65.562 511.834,67.743 512.574,69.651 C513.342,71.625 514.368,73.296 516.035,74.965 C517.703,76.634 519.376,77.658 521.349,78.425 C523.257,79.167 525.438,79.673 528.631,79.82 C531.831,79.965 532.853,80.001 541,80.001 C549.148,80.001 550.169,79.965 553.369,79.82 C556.562,79.673 558.743,79.167 560.652,78.425 C562.623,77.658 564.297,76.634 565.965,74.965 C567.633,73.296 568.659,71.625 569.425,69.651 C570.167,67.743 570.674,65.562 570.82,62.369 C570.966,59.17 571,58.147 571,50 C571,41.851 570.966,40.831 570.82,37.631\"><\/path><\/g><\/g><\/g><\/svg><\/div><div style=\"padding-top: 8px;\"> <div style=\" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;\"> View this post on Instagram<\/div><\/div><div style=\"padding: 12.5% 0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div><\/a> <p style=\" margin:8px 0 0 0; padding:0 4px;\"> <a href=\"https:\/\/www.instagram.com\/p\/CFPhHchsE_H\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#000; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none; word-wrap:break-word;\" target=\"_blank\" rel=\"noopener noreferrer\">Dealing with aging is a multi-layered experience. I take good care of my skin, hydrate and exercise, but sometimes a girl needs a little extra help. I was excited to try @xeominaesthetic (incobotulinumtoxinA) for my frown lines, it&rsquo;s a uniquely purified anti-wrinkle injection that does not contain any unnecessary proteins. I am a big fan. #laterfrownlines #helloXeomin &hellip;. Studies have not been performed to determine whether the presence or absence of unnecessary\/complexing proteins has a long-term effect on safety or efficacy. Individual results may vary. For full Prescribing Information including BOXED WARNING and Medication Guide, see @xeominaestheticpi. Xeomin&reg; is an FDA-approved treatment used to temporarily improve the look of moderate to severe frown lines between the eyebrows (glabellar lines) in adults. Ask your doctor to tell you all about Xeomin. The effects of Xeomin may spread hours to weeks after injection causing serious symptoms. Alert your doctor right away as difficulty swallowing, speaking, breathing, eye problems or muscle weakness can be a sign of a life-threatening condition. Side effects may include allergic reactions or injection-site pain, eyelid drooping, and swelling. Xeomin is available by prescription only.<\/a><\/p> <p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\">A post shared by <a href=\"https:\/\/www.instagram.com\/gwynethpaltrow\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px;\" target=\"_blank\" rel=\"noopener noreferrer\"> Gwyneth Paltrow<\/a> (@gwynethpaltrow) on <time style=\" font-family:Arial,sans-serif; font-size:14px; line-height:17px;\" datetime=\"2020-09-17T15:20:25+00:00\">Sep 17, 2020 at 8:20am PDT<\/time><\/p><\/div><\/blockquote> <script async=\"\" src=\"\/\/www.instagram.com\/embed.js\"><\/script><\/center><p>&ldquo;Gwyneth has a lot of celebrity,&rdquo; says <a href=\"https:\/\/www.realself.com\/dr\/jason-d-bloom-bryn-mawr-pa\">Dr. Jason Bloom<\/a>, a double board-certified facial plastic surgeon in Philadelphia. &ldquo;Her Goop line is clean and pure, and people who believe in that are coming in and asking for Xeomin. Some of my patients say they prefer a purified neurotoxin without any additional proteins.&rdquo;<\/p><p>He&mdash;and Gwyneth&mdash;are referring to complexing proteins, or the non-active proteins that surround the active ingredient, botulinum toxin type A, in injectable toxins such as <a href=\"https:\/\/www.realself.com\/botox\">Botox<\/a>, <a href=\"https:\/\/www.realself.com\/nonsurgical\/jeuveau\">Jeuveau<\/a>, and <a href=\"https:\/\/www.realself.com\/dysport\">Dysport<\/a>. While the role these proteins play is somewhat unclear, they&rsquo;re thought to aid in the delivery and stability of the toxin. &ldquo;Think of complexing proteins as a carrying mechanism, like a cell phone case with a loop, ring, or lanyard that you put on your cell phone,&rdquo; says <a href=\"https:\/\/www.realself.com\/dr\/heidi-a-waldorf-nanuet-ny\">Dr. Heidi Waldorf,<\/a> a board-certified dermatologist in Nanuet, New York. &ldquo;The complexing proteins don&rsquo;t necessarily surround the botulinum toxin molecule but attach to it.&rdquo;<\/p><div id=\"doctorCTA_shortcode\" style=\"text-align:center;\"><div style=\"color: rgba(0,0,0,.5);margin-bottom:10px;\"><small>Interested in Xeomin?<\/small><\/div><a class=\"button\" href=\"https:\/\/www.realself.com\/drsearch?keyword=Xeomin\" style=\"padding: 15px;margin-top: 0px;margin-bottom: 1.75rem;width: 300px;max-width: 100%;\">Find Doctors Near You<\/a><\/div><p>Xeomin, however, is more akin to slipping an unadorned iPhone into your back pocket&mdash;a &ldquo;naked&rdquo; form of the toxin. &ldquo;There are different proteins around the [botulinum toxin] molecule in Botox and Dysport,&rdquo; says Dr. Bloom, &ldquo;but there are no additional proteins around the molecule in Xeomin.&rdquo; This stripped-down formulation is simpler, but the absence of complexing proteins may not matter in practical terms, as those in other toxins don&rsquo;t hang around that long in the first place. &ldquo;Within seconds after adding saline to reconstitute [Botox], <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0041010110004502?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">the proteins around it dissociate anyway<\/a>,&rdquo; Dr. Bloom says.&nbsp;<\/p><p>Even so, there&rsquo;s a theory that Xeomin&rsquo;s absence of these proteins keeps the body from forming antibodies to it, simply by giving the body less to potentially react to. In turn, that would make it less likely to lead to drug resistance over time&mdash;a relevant concern, given how many twentysomethings begin using toxins years before their first wrinkles set in. &ldquo;Theoretically, you could get antibodies to Botox or Dysport,&rdquo; says Dr. Bloom. &ldquo;There are cases of patients who&rsquo;ve been getting Botox for 10 years and find that it&rsquo;s not lasting as long.&rdquo; In those cases, he says, switching to a different brand may make a difference.<\/p><p>But, doctors say, resistance is rare. &ldquo;I&rsquo;ve treated thousands of patients with different toxins, and I have one patient who doesn&rsquo;t respond at all,&rdquo; says <a href=\"https:\/\/www.realself.com\/dr\/sarmela-sunder-beverly-hills-ca\">Dr. Sarmela Sunder<\/a>, a double board-certified facial plastic surgeon in Beverly Hills, California. However, she explains, this patient had been using an earlier version of Botox&mdash;which contained five times the complexing proteins of today&rsquo;s formula&mdash;before it was approved for cosmetic uses in 2002. &ldquo;That cohort of patients who received those initial versions of Botox have a higher degree of developing antibodies and becoming resistant to it,&rdquo; she says. &ldquo;[Among others,] it&rsquo;s exceedingly rare.&rdquo;&nbsp;&nbsp;<\/p><p><em>Related: <a href=\"https:\/\/www.realself.com\/news\/neurotoxins-botox-dysport-xeomin-jeuveau\">Botox, Dysport, Xeomin, or Jeuveau: What&rsquo;s the Difference?<\/a><\/em><\/p><p>Fortunately, whether you&rsquo;re considering Xeomin or one of its competitors, all these drugs have been evaluated to ensure safety. Dr. Waldorf notes that all FDA-approved botulinum toxins are prepared under strict conditions. &ldquo;Patients should feel reassured that if their physician is buying an FDA-approved botulinum directly from the manufacturer or official distributor in the USA, it follows safety and sterility guidelines,&rdquo; she says. And from a results standpoint, though the units required may differ from one brand to another, &ldquo;a toxin is a toxin,&rdquo; according to Dr. Sunder. &ldquo;Not having complexing proteins doesn&rsquo;t make Xeomin better,&rdquo; she says. Indeed, a <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00702-019-02023-x?shared-article-renderer\" target=\"_blank\" rel=\"noreferrer noopener\">2019 study<\/a> found that complexing proteins do not affect the stability or efficacy of the formulation.&nbsp;&nbsp;<\/p><p>So is Xeomin the right choice for you? Only you and your doctor can decide. &ldquo;In my practice, a toxin without complexing proteins &hellip;&nbsp;is particularly attractive to patients who have multiple or unusual allergies, autoimmune disorders, or, simply, a complicated medical history,&rdquo; Dr. Waldorf says. It may also appeal to a select set of pro-toxin vegans and clean-lifestyle enthusiasts, since Xeomin is the only toxin that doesn&rsquo;t contain human serum albumin. For others, the results will speak for themselves. &ldquo;I do have patients who feel one botulinum toxin works better than the other for them, but those are individual preferences,&rdquo; she adds.&nbsp;<\/p><p>Whether you prefer your toxin with proteins or not, one thing is certain: the growing interest in clean beauty formulations, not to mention the power of celebrity, means the buzz on Xeomin is growing. Merz Aesthetics, the parent company, is keeping mum on exact figures, but a representative reports that Xeomin is now the fastest-growing neurotoxin in the U.S. medical aesthetics market.&nbsp;&nbsp;&nbsp;<\/p><div id=\"doctorCTA_shortcode\" style=\"text-align:center;\"><div style=\"color: rgba(0,0,0,.5);margin-bottom:10px;\"><small>Interested in Xeomin?<\/small><\/div><a class=\"button\" href=\"https:\/\/www.realself.com\/drsearch?keyword=Xeomin\" style=\"padding: 15px;margin-top: 0px;margin-bottom: 1.75rem;width: 300px;max-width: 100%;\">Find Doctors Near You<\/a><\/div><div class=\"newsletter-signup\" id=\"newsletterForm\">\n    <h2 class=\"newsletter-signup__heading\" id=\"unlock-a-world-of-modern-beauty\">Unlock a world of modern beauty<\/h2>\n    <p class=\"newsletter-signup__text\">Stay up-to-date on trending news, popular procedures, and exclusive content.<\/p>\n    <div class=\"newsletter-signup__wrapper\">\n        <input class=\"newsletter-signup__input\" type=\"email\" id=\"newsletterEmail\" placeholder=\"Enter your email\">\n        <button class=\"newsletter-signup__button button\" onclick=\"submitEmail()\">SUBSCRIBE<\/button>\n    <\/div>\n    <div class=\"newsletter-signup__small\"><p><span style=\"font-weight: 400;\">By subscribing, you accept our <\/span><a href=\"https:\/\/www.realself.com\/real_self_privacy_policy.html\"><span style=\"font-weight: 400;\">Privacy Policy<\/span><\/a><span style=\"font-weight: 400;\"> and <\/span><a href=\"https:\/\/www.realself.com\/terms-of-service\"><span style=\"font-weight: 400;\">Terms of Service<\/span><\/a><span style=\"font-weight: 400;\"> and agree to receive marketing emails.<\/span><\/p>\n<\/div>\n    <div id=\"newsletter-message\" class=\"newsletter-signup__message\"><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Gwyneth Paltrow\u2019s latest beauty recommendation is Xeomin, an injectable wrinkle reducer. Xeomin is marketed as \u201cclean\u201d; learn what doctors say that entails.<\/p>\n","protected":false},"author":128,"featured_media":17326,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9075],"tags":[12165,24,18234,12522,9954,2323],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v20.0 (Yoast SEO v23.0) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Xeomin\u2014The &quot;Clean&quot; Botox Alternative | RealSelf News<\/title>\n<meta name=\"description\" content=\"Gwyneth Paltrow\u2019s latest beauty recommendation is Xeomin, an injectable wrinkle reducer. Xeomin is marketed as \u201cclean\u201d; learn what doctors say that entails.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https://www.realself.com\/news\/xeomin-botox-alternative\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The &quot;Fastest-Growing Neurotoxin&quot; in the U.S. Markets Itself as \u201cClean.\u201d Docs Reveal What That Actually Means.\" \/>\n<meta property=\"og:description\" content=\"Gwyneth Paltrow\u2019s latest beauty recommendation is Xeomin, an injectable wrinkle reducer. 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