Columbia Dermatologist
2011 Corona Rd, Suite 207
Columbia, Missouri 65203 US
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Treatment Pricing

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22 years experience
28 expert answers
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Board Certifications

Board-certified by the American Board of Dermatology


American Academy of Dermatology (AAD)

Consultation Fee

Free. Consultation by esthetician or esthetic nurse is at no charge.

Hospital Privileges

Dr. DeSpain has hospital affiliations at Boone Hospital.


  • Undergraduate & Medical School

    Undergraduate: BA in Biologic Sciences, University of Missouri - Columbia
    Medical: MD, University of Missouri - Columbia
  • Post-Medical School Training

    Internship: Denver, CO
    Residency: Dermatology, Mizzou
    Fellowship: Dermatopathology, Denver, CO

Treatments offered at DeSpain Cayce Dermatology Center and Medical Spa

Most popular answers from John DeSpain, MD

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How can you tell if your doctor is using the real Juvaderm/juvaderm voluma filler or an alternative?

Great question! First I'd only have a board certified Derm or Plastics doctor inject. Check the Allergan website to verify the doc is listed as one of... READ MORE

Is this Actinic Keratosis? (photos)

You do seem young and have very little sun damage, so I'd be a bit tentative about that diagnosis as well. Try a moisturizer on the area for a week or... READ MORE

Which one is the better treatment for wrinkles, age spots and large pores, Ultherapy vs. Thermage?

Ultherapy and Thermage (or other tissue tightening procedures whether they use RF or ultrasound) target several millimeters deep in the tissue. Your... READ MORE

23 years old. What are my BEST options? (Photo)

Actually if properly injected you may be a great candidate for a low dose of botox. Seek a provider (Derm or Plastic Surgeon who injects, not a... READ MORE

What is the Best Treatment for the Deepest Lines on Hands?

Would have to examine to help with this one but I would consider a resurfacing laser to undo surface lines and texture and/ or injecting filler such... READ MORE

I believe juvederm hit my lip nerve and my lip is huge. Should I go back to get it reversed? I really dislike it (Photo)

I would strongly encourage you to contact the injector today. They should be available to see you. This could represent a hematoma (blood from a... READ MORE

Do I need all this treatment or are they just trying to up-sale me?

I'd suggest consultation face to face w/whomever will be offering the procedure. Every case we treat is different. We did use Ultherapy in our... READ MORE

Can I get a mole removed from my vagina?

Actually as scary as this sounds in skilled hands its a pretty gentle, simple procedure. I'd consult w/the dermatologist in your area! READ MORE

What are your opinion on fillers/Botox with melasma patients?

Melasma will not be effected by botox or fillers. You are at no more risk than any other patient to have these treatments! READ MORE

What do you think is the procedure that will greatly improve my scars? (Photo)

You have pitted, rolling, and boxcar scars. Its not uncommon to have a variety of scar types, and we offer a variety of options which might be... READ MORE

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*Your results may vary. Any specific claims or permanence length of results vary for each patient and are not guaranteed.