Short answer - yes! There are some people who just stop responding to Botox. Most commonly it's because of antibodies that stick to the Botox molecule and prevent it from acting on the treated muscle. In order to reduce the chance of these antibodies forming, we usually recommend using the smallest (effective) dose, avoiding "booster" injections and making sure that you wait the full 3 months prior to getting Botox again. Thankfully, there are multiple alternatives to Botox you can use if aren't responding. Dysport, Xeomin, Jeuveau are the more common ones. Daxxify is a newer neuromodulator that is supposed to last a bit longer but not widely available at this point.
